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dc.contributor.authorLonergan, Roisin
dc.contributor.authorCarthy, Fiona
dc.contributor.authorAlexander, Michael
dc.contributor.authorRoberts, Kinley
dc.contributor.authorFarrell, Michael
dc.contributor.authorLynch, Timothy
dc.date.accessioned2013-10-14T15:31:52Z
dc.date.available2013-10-14T15:31:52Z
dc.date.issued2013-11
dc.identifier.citationPICK 'N' MIX: NEUROPATHOLOGICAL DETECTION OF PERI-TUMOUR TAUOPATHY. 2013, 84 (11):e2 J. Neurol. Neurosurg. Psychiatr.en_GB
dc.identifier.issn1468-330X
dc.identifier.pmid24109071
dc.identifier.doi10.1136/jnnp-2013-306573.85
dc.identifier.urihttp://hdl.handle.net/10147/303415
dc.description.abstractRadiotherapy is used to treat recurrent oligodendrogliomas, WHO grade 2 tumours. Potential morbitities include steroid-responsive radiation necrosis and radiation leucoencephalopathy, characterised pathologically by reactive astrogliosis, focal necrosis, demyelination, axonal loss, and clinically by progressive subcortical deficits (ataxia, amnesia, incontinence, cognitive decline), with relative sparing of cortical function. Although subcortical features may overlap with neurodegenerative conditions (eg frontotemporal dementia), focal cortical atrophy of FTD causes loss of language function in addition to memory, and specific histopathological features characterise FTD subtypes (eg Pick disease). Association between mitotic disease and tauopathy has not been reported widely, but co-existence is possible. Diagnostic accuracy may guide management.
dc.languageENG
dc.rightsArchived with thanks to Journal of neurology, neurosurgery, and psychiatryen_GB
dc.subjectRADIOTHERAPYen_GB
dc.subjectCANCERen_GB
dc.subject.otherTUMOURen_GB
dc.titlePick 'n' mix: neuropatholgical detection of peri-tumour taupathy.en_GB
dc.typeArticleen
dc.contributor.departmentMater Misericordiae Hospital; Neuropathology Department Beaumont Hospital.en_GB
dc.identifier.journalJournal of neurology, neurosurgery, and psychiatryen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
html.description.abstractRadiotherapy is used to treat recurrent oligodendrogliomas, WHO grade 2 tumours. Potential morbitities include steroid-responsive radiation necrosis and radiation leucoencephalopathy, characterised pathologically by reactive astrogliosis, focal necrosis, demyelination, axonal loss, and clinically by progressive subcortical deficits (ataxia, amnesia, incontinence, cognitive decline), with relative sparing of cortical function. Although subcortical features may overlap with neurodegenerative conditions (eg frontotemporal dementia), focal cortical atrophy of FTD causes loss of language function in addition to memory, and specific histopathological features characterise FTD subtypes (eg Pick disease). Association between mitotic disease and tauopathy has not been reported widely, but co-existence is possible. Diagnostic accuracy may guide management.


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