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    Treatment of Helicobacter pylori Infection 2013.

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    Authors
    O'Connor, Anthony
    Molina-Infante, Javier
    Gisbert, Javier P
    O'Morain, Colm
    Affiliation
    Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Tallaght, Dublin, Ireland.
    Issue Date
    2013-09
    
    Metadata
    Show full item record
    Citation
    Treatment of Helicobacter pylori Infection 2013. 2013, 18 Suppl 1:58-65 Helicobacter
    Journal
    Helicobacter
    URI
    http://hdl.handle.net/10147/302015
    DOI
    10.1111/hel.12075
    PubMed ID
    24011247
    Abstract
    This review summarizes important studies regarding Helicobacter pylori therapy published from April 2012 up to March 2013. To begin with, the updated European Consensus Guidelines were published last year, highlighting the role of bismuth and nonbismuth quadruple regimen as first-line treatments. Cure rates for standard triple therapy remain acceptable in quite a few settings nowadays, and some reports on innovative triple therapies look promising. One study evaluating bismuth quadruple therapy as first-line therapy was reported. Regarding nonbismuth quadruple regimens, there is a trend of superiority emerging for the "concomitant" therapy over the "sequential" regimen. "Hybrid" therapy, a combination of sequential and concomitant therapy, has also shown advantage over sequential therapy. Levofloxacin-based therapies appear to be useful and versatile in second- and third-line therapies, with interesting results for newer generation quinolones, which may partially overcome antibiotic resistance. Some promising works have been reported for bismuth-based rescue therapy, using individualized therapies upon antimicrobial information, as well as for rifabutin fourth-line therapy. Probiotics appear to have an effect in terms of reducing side effects and improving compliance, but data on improvement of eradication rates remain controversial.
    Item Type
    Article
    Language
    en
    ISSN
    1523-5378
    ae974a485f413a2113503eed53cd6c53
    10.1111/hel.12075
    Scopus Count
    Collections
    Tallaght University Hospital

    entitlement

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