Affiliation
Department of Neonatology, National Maternity Hospital, Holles Street, Dublin, Ireland. dee.sweetman@gmail.comIssue Date
2013-03Keywords
NEONATEMeSH
Acute Kidney InjuryBiological Markers
Gestational Age
Humans
Hypoxia-Ischemia, Brain
Infant, Newborn
Metadata
Show full item recordCitation
Biomarkers of acute kidney injury in neonatal encephalopathy. 2013, 172 (3):305-16 Eur. J. Pediatr.Journal
European journal of pediatricsDOI
10.1007/s00431-012-1890-6PubMed ID
23138391Abstract
Acute kidney injury (AKI) is a common complication of neonatal encephalopathy (NE). The accurate diagnosis of neonatal AKI, irrespective of the cause, relies on suboptimal methods such as identification of rising serum creatinine, decreased urinary output and glomerular filtration rate. Studies of AKI biomarkers in adults and children have shown that biomarkers can improve the early diagnosis of AKI. Hypoxia-ischaemia is the proposed aetiological basis of AKI in both NE and cardiopulmonary bypass (CPB). However, there is a paucity of studies examining the role of AKI biomarkers specifically in NE. Urinary cystatin C (CysC), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18, kidney injury molecule-1, liver-type fatty acid-binding protein, serum CysC and serum NGAL all show good ability to predict early AKI in a heterogeneous critically ill neonatal population including infants post-CPB. Moreover, serum and urinary NGAL and urinary CysC are early predictors of AKI secondary to NE. These findings are promising and open up the possibility of biomarkers playing a significant role in the early diagnosis and treatment of NE-related AKI. There is an urgent need to explore the role of AKI biomarkers in infants with NE as establishing the diagnosis of AKI earlier may allow more timely intervention with potential for improving long-term outcome.Item Type
ArticleLanguage
enISSN
1432-1076ae974a485f413a2113503eed53cd6c53
10.1007/s00431-012-1890-6
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