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    Biomarkers of acute kidney injury in neonatal encephalopathy.

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    Authors
    Sweetman, D U
    Molloy, E J
    Affiliation
    Department of Neonatology, National Maternity Hospital, Holles Street, Dublin, Ireland. dee.sweetman@gmail.com
    Issue Date
    2013-03
    Keywords
    NEONATE
    MeSH
    Acute Kidney Injury
    Biological Markers
    Gestational Age
    Humans
    Hypoxia-Ischemia, Brain
    Infant, Newborn
    
    Metadata
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    Citation
    Biomarkers of acute kidney injury in neonatal encephalopathy. 2013, 172 (3):305-16 Eur. J. Pediatr.
    Journal
    European journal of pediatrics
    URI
    http://hdl.handle.net/10147/300394
    DOI
    10.1007/s00431-012-1890-6
    PubMed ID
    23138391
    Abstract
    Acute kidney injury (AKI) is a common complication of neonatal encephalopathy (NE). The accurate diagnosis of neonatal AKI, irrespective of the cause, relies on suboptimal methods such as identification of rising serum creatinine, decreased urinary output and glomerular filtration rate. Studies of AKI biomarkers in adults and children have shown that biomarkers can improve the early diagnosis of AKI. Hypoxia-ischaemia is the proposed aetiological basis of AKI in both NE and cardiopulmonary bypass (CPB). However, there is a paucity of studies examining the role of AKI biomarkers specifically in NE. Urinary cystatin C (CysC), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18, kidney injury molecule-1, liver-type fatty acid-binding protein, serum CysC and serum NGAL all show good ability to predict early AKI in a heterogeneous critically ill neonatal population including infants post-CPB. Moreover, serum and urinary NGAL and urinary CysC are early predictors of AKI secondary to NE. These findings are promising and open up the possibility of biomarkers playing a significant role in the early diagnosis and treatment of NE-related AKI. There is an urgent need to explore the role of AKI biomarkers in infants with NE as establishing the diagnosis of AKI earlier may allow more timely intervention with potential for improving long-term outcome.
    Item Type
    Article
    Language
    en
    ISSN
    1432-1076
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00431-012-1890-6
    Scopus Count
    Collections
    National Maternity Hospital Holles St.

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