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dc.contributor.authorKelly, E G
dc.contributor.authorCashman, J P
dc.date.accessioned2013-07-22T13:27:23Z
dc.date.available2013-07-22T13:27:23Z
dc.date.issued2013-02
dc.identifier.citationLeucocyte esterase in the rapid diagnosis of paediatric septic arthritis. 2013, 80 (2):191-3 Med. Hypothesesen_GB
dc.identifier.issn1532-2777
dc.identifier.pmid23257651
dc.identifier.doi10.1016/j.mehy.2012.11.026
dc.identifier.urihttp://hdl.handle.net/10147/296786
dc.description.abstractSeptic arthritis may affect any age group but is more common in the paediatric population. Infection is generally bacterial in nature. Prompt diagnosis is crucial, as delayed treatment is associated with lifelong joint dysfunction. A clinical history and application of Kocher's criteria may indicate that there is a septic arthritis. However, definitive diagnosis is made on culture of septic synovial fluid. The culture process can take over 24h for the initial culture to yield bacterial colonies. Leucocyte esterase is released by leucocytes at the site of an infection. We hypothesise that leucocyte esterase can be utilized in the rapid diagnosis of septic arthritis and shorten the time to decisive treatment whilst simultaneously decreasing unnecessary treatment of non-septic joints.
dc.language.isoenen
dc.rightsArchived with thanks to Medical hypothesesen_GB
dc.subject.meshArthritis, Infectious
dc.subject.meshCarboxylic Ester Hydrolases
dc.subject.meshChild
dc.subject.meshHumans
dc.subject.meshModels, Biological
dc.subject.meshSynovial Fluid
dc.subject.meshTime Factors
dc.titleLeucocyte esterase in the rapid diagnosis of paediatric septic arthritis.en_GB
dc.typeArticleen
dc.contributor.departmentDept. of Trauma and Orthopaedic Surgery, Children's University Hospital, Temple St., Dublin, Ireland. endagkelly@gmail.comen_GB
dc.identifier.journalMedical hypothesesen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
html.description.abstractSeptic arthritis may affect any age group but is more common in the paediatric population. Infection is generally bacterial in nature. Prompt diagnosis is crucial, as delayed treatment is associated with lifelong joint dysfunction. A clinical history and application of Kocher's criteria may indicate that there is a septic arthritis. However, definitive diagnosis is made on culture of septic synovial fluid. The culture process can take over 24h for the initial culture to yield bacterial colonies. Leucocyte esterase is released by leucocytes at the site of an infection. We hypothesise that leucocyte esterase can be utilized in the rapid diagnosis of septic arthritis and shorten the time to decisive treatment whilst simultaneously decreasing unnecessary treatment of non-septic joints.


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