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dc.contributor.authorStevens, Niall T
dc.contributor.authorGreene, Catherine M
dc.contributor.authorO'Gara, James P
dc.contributor.authorBayston, Roger
dc.contributor.authorSattar, Muhammad T A
dc.contributor.authorFarrell, Michael
dc.contributor.authorHumphreys, Hilary
dc.date.accessioned2013-07-22T08:57:57Z
dc.date.available2013-07-22T08:57:57Z
dc.date.issued2012-12
dc.identifier.citationVentriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment. 2012, 26 (6):792-7 Br J Neurosurgen_GB
dc.identifier.issn1360-046X
dc.identifier.pmid22303864
dc.identifier.doi10.3109/02688697.2011.651514
dc.identifier.urihttp://hdl.handle.net/10147/296745
dc.description.abstractThe insertion of medical devices, such as intraventricular shunts, is often complicated by infection leading to ventriculitis. Frequently, such infections result from colonisation and subsequent biofilm formation on the surfaces of the shunts by Staphylococcus epidermidis. The pathogenesis of neurosurgical shunt-related infection is complex with interactions between the pathogen, the device and the unique local immunological environment of the central nervous system (CNS). An ability to form biofilm, the main virulence determinant of Staphylococcus epidermidis, facilitates protection of the organism from the host defences while still initiating an immunological response. The presence of the blood brain barrier (BBB) and the biofilm itself also complicates treatment, which presents many challenges when managing shunt infections. A greater understanding of the interplay between S. epidermidis and the CNS could potentially improve the diagnosis, treatment and management of such infections. This review describes the pathogenesis, treatment and implications of S. epidermidis ventriculoperitoneal shunt-related infections, concentrating on recent research and the implications for treatment.
dc.language.isoenen
dc.rightsArchived with thanks to British journal of neurosurgeryen_GB
dc.subject.meshHumans
dc.subject.meshPostoperative Complications
dc.subject.meshStaphylococcal Infections
dc.subject.meshStaphylococcus epidermidis
dc.subject.meshVentriculoperitoneal Shunt
dc.titleVentriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Microbiology, Royal College of Surgeons in Ireland, Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland. nstevens@rcsi.ieen_GB
dc.identifier.journalBritish journal of neurosurgeryen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
html.description.abstractThe insertion of medical devices, such as intraventricular shunts, is often complicated by infection leading to ventriculitis. Frequently, such infections result from colonisation and subsequent biofilm formation on the surfaces of the shunts by Staphylococcus epidermidis. The pathogenesis of neurosurgical shunt-related infection is complex with interactions between the pathogen, the device and the unique local immunological environment of the central nervous system (CNS). An ability to form biofilm, the main virulence determinant of Staphylococcus epidermidis, facilitates protection of the organism from the host defences while still initiating an immunological response. The presence of the blood brain barrier (BBB) and the biofilm itself also complicates treatment, which presents many challenges when managing shunt infections. A greater understanding of the interplay between S. epidermidis and the CNS could potentially improve the diagnosis, treatment and management of such infections. This review describes the pathogenesis, treatment and implications of S. epidermidis ventriculoperitoneal shunt-related infections, concentrating on recent research and the implications for treatment.


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