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    Aspirin as a chemoprevention agent for colorectal cancer.

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    Authors
    Lee, Chun Seng
    McNamara, Deirdre
    O'Morain, Colm A
    Affiliation
    Department of Clinical Medicine, Trinity Centre for Health sciences, Adelaide and Meath, Hospital, Dublin, Ireland. chunseng75@yahoo.co.uk
    Issue Date
    2012-11
    MeSH
    Animals
    Anti-Inflammatory Agents, Non-Steroidal
    Anticarcinogenic Agents
    Aspirin
    Colorectal Neoplasms
    Cost-Benefit Analysis
    Humans
    
    Metadata
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    Citation
    Aspirin as a chemoprevention agent for colorectal cancer. 2012, 13 (9):1313-22 Curr. Drug Metab.
    Journal
    Current drug metabolism
    URI
    http://hdl.handle.net/10147/296530
    PubMed ID
    22493984
    Abstract
    Colorectal cancer (CRC) is one of the leading causes of mortality in the western world. It is widely accepted that neoplasms such as colonic polyps are precursors to CRC formation; with the polyp-adenoma-carcinoma sequences well described in medical literature [1, 2]. It has been shown that Aspirin and other non-steroid anti-inflammatory drugs (NSAID) have a negative effect on polyp and cancer formation. This review aims to describe some of the mechanism behind the chemoprotective properties of aspirin; COX 2 inhibition, regulation of proliferation and apoptosis and effects on the immune system and also the current evidence that supports its use as a chemoprevention agent against CRC. We will also aim to explore the side effects with the use of aspirin and the pitfalls of using aspirin routinely for primary prophylaxis against CRC.
    Item Type
    Article
    Language
    en
    ISSN
    1875-5453
    Collections
    Tallaght University Hospital

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