• Login
    View Item 
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4708
    UlsterS
    4708
    Connacht
    1606
    Munster
    48
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementRIAN Pathways to Irish ResearchHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Display statistics

    Modern antiplatelet agents in coronary artery disease.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Power, Rachel F
    Hynes, Brian G
    Moran, Darragh
    Yagoub, Hatim
    Kiernan, Gary
    Ruggiero, Nicholas J
    Kiernan, Thomas J
    Affiliation
    Department of Interventional Cardiology, Cork University Hospital, University College Cork School of Medicine, Cork, Ireland.
    Issue Date
    2012-10
    MeSH
    Animals
    Coronary Artery Disease
    Drug Design
    Drug Therapy, Combination
    Humans
    Individualized Medicine
    Platelet Aggregation Inhibitors
    Purinergic P2Y Receptor Antagonists
    Receptor, PAR-1
    Receptors, Purinergic P2Y12
    
    Metadata
    Show full item record
    Citation
    Modern antiplatelet agents in coronary artery disease. 2012, 10 (10):1261-72 Expert Rev Cardiovasc Ther
    Journal
    Expert review of cardiovascular therapy
    URI
    http://hdl.handle.net/10147/292584
    DOI
    10.1586/erc.12.127
    PubMed ID
    23190065
    Abstract
    Dual antiplatelet therapy is well recognized in the prevention of thrombotic complications of acute coronary syndrome and percutaneous coronary interventions. Despite clinical benefits of aspirin and clopidogrel therapy, a number of limitations curtail their efficacy: slow onset of action, variability in platelet inhibitory response and potential drug-drug interactions. Furthermore, the single platelet-activation pathway targeted by these agents allows continued platelet activation via other pathways, ensuring incomplete protection against ischemic events, thus, underscoring the need for alternate antiplatelet treatment strategies. A number of novel antiplatelet agents are currently in advance development and many have established superior effects on platelet inhibition, clinical outcomes and safety profile than clopidogrel in high-risk patients. The aim of this review is to provide an overview of the current status of P2Y12 receptor inhibition and PAR-1 antagonists in determining a future strategy for individualized antiplatelet therapy.
    Language
    en
    ISSN
    1744-8344
    ae974a485f413a2113503eed53cd6c53
    10.1586/erc.12.127
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

     
    National Health Library & Knowledge Service | Health Service Executive | Dr Steevens' Hospital | Dublin 8 | Ireland
    lenus@hse.ie | Tel +353 (1) 6352558
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.