Early life adversity is associated with brain changes in subjects at family risk for depression.
Authors
Carballedo, AngelaLisiecka, Danutia
Fagan, Andrew
Saleh, Karim
Ferguson, Yolande
Connolly, Gerard
Meaney, James
Frodl, Thomas
Affiliation
Department of Psychiatry, Institute of Neuroscience, Adelaide and Meath Hospital incorporating the National Children's Hospital (AMNCH), St. James's Hospital and Centre of Advanced Medical Imaging (CAMI), University Dublin, Trinity College, Ireland.Issue Date
2012-12MeSH
AdultChild
Child Abuse
Depressive Disorder, Major
Female
Frontal Lobe
Genetic Predisposition to Disease
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Risk
Metadata
Show full item recordCitation
Early life adversity is associated with brain changes in subjects at family risk for depression. 2012, 13 (8):569-78 World J. Biol. PsychiatryJournal
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological PsychiatryDOI
10.3109/15622975.2012.661079PubMed ID
22515408Abstract
The interplay of genetic and early environmental factors is recognized as an important factor in the aetiology of major depressive disorder (MDD). The aim of the present study was to examine whether reduced volume of hippocampus and frontal brain regions involved in emotional regulation are already present in unaffected healthy individuals at genetic risk of suffering MDD and to investigate whether early life adversity is a relevant factor interacting with these reduced brain structures.Item Type
ArticleLanguage
enISSN
1814-1412ae974a485f413a2113503eed53cd6c53
10.3109/15622975.2012.661079