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Authors
Saleh, KarimCarballedo, Angela
Lisiecka, Danutia
Fagan, Andrew J
Connolly, Gerald
Boyle, Gerard
Frodl, Thomas
Affiliation
Department of Psychiatry St. James's Hospital and Adelaide and Meath Hospital incorporating the National Children's Hospital, Trinity College Dublin, Ireland.Issue Date
2012-07-30MeSH
AdultAmygdala
Case-Control Studies
Depressive Disorder, Major
Family
Female
Functional Laterality
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
Risk Factors
Sex Factors
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Impact of family history and depression on amygdala volume. 2012, 203 (1):24-30 Psychiatry ResJournal
Psychiatry researchDOI
10.1016/j.pscychresns.2011.10.004PubMed ID
22867951Abstract
Family history of depression significantly impacts life-long depression risk. Family history could impact the stress and emotion regulation system that involves the amygdala. This study's purpose was to investigate family history's effect on amygdala volumes, and differences in first degree relatives with and without major depressive disorder (MDD). Participants, aged 18-65, were healthy volunteers (N=52) with (n=26) and without (n=26) first degree family history, and patients with MDD (N=48) with (n=27) and without (n=21)first-degree family history recruited for structural magnetic resonance imaging (MRI). Participants underwent clinical assessment followed by manual amygdala tracing. Patients with MDD without family history showed significantly larger right amygdala without a family history of MDD. These effects had larger right amygdala than healthy controls without MDD family history. These effects were pronounced in females. Family history and gender impacted amygdala volumes in all participants, providing a rationale for the inconsistent results in MDD amygdala studies. Higher familial risk in depression seems to be associated with smaller amygdala volumes, whereas depression alone is associated with larger amygdala volumes. Ultimately, these findings highlight consideration of family history and gender in research and treatment strategies.Item Type
ArticleLanguage
enISSN
1872-7123ae974a485f413a2113503eed53cd6c53
10.1016/j.pscychresns.2011.10.004
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