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    Impact of family history and depression on amygdala volume.

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    Authors
    Saleh, Karim
    Carballedo, Angela
    Lisiecka, Danutia
    Fagan, Andrew J
    Connolly, Gerald
    Boyle, Gerard
    Frodl, Thomas
    Affiliation
    Department of Psychiatry St. James's Hospital and Adelaide and Meath Hospital incorporating the National Children's Hospital, Trinity College Dublin, Ireland.
    Issue Date
    2012-07-30
    MeSH
    Adult
    Amygdala
    Case-Control Studies
    Depressive Disorder, Major
    Family
    Female
    Functional Laterality
    Humans
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Organ Size
    Risk Factors
    Sex Factors
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    Citation
    Impact of family history and depression on amygdala volume. 2012, 203 (1):24-30 Psychiatry Res
    Journal
    Psychiatry research
    URI
    http://hdl.handle.net/10147/292580
    DOI
    10.1016/j.pscychresns.2011.10.004
    PubMed ID
    22867951
    Abstract
    Family history of depression significantly impacts life-long depression risk. Family history could impact the stress and emotion regulation system that involves the amygdala. This study's purpose was to investigate family history's effect on amygdala volumes, and differences in first degree relatives with and without major depressive disorder (MDD). Participants, aged 18-65, were healthy volunteers (N=52) with (n=26) and without (n=26) first degree family history, and patients with MDD (N=48) with (n=27) and without (n=21)first-degree family history recruited for structural magnetic resonance imaging (MRI). Participants underwent clinical assessment followed by manual amygdala tracing. Patients with MDD without family history showed significantly larger right amygdala without a family history of MDD. These effects had larger right amygdala than healthy controls without MDD family history. These effects were pronounced in females. Family history and gender impacted amygdala volumes in all participants, providing a rationale for the inconsistent results in MDD amygdala studies. Higher familial risk in depression seems to be associated with smaller amygdala volumes, whereas depression alone is associated with larger amygdala volumes. Ultimately, these findings highlight consideration of family history and gender in research and treatment strategies.
    Item Type
    Article
    Language
    en
    ISSN
    1872-7123
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.pscychresns.2011.10.004
    Scopus Count
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    St. James's Hospital

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