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Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis.

dc.contributor.authorSchulz, Bettina
dc.contributor.authorKnobloch, Mathias
dc.contributor.authorMoran, Gary P
dc.contributor.authorWeber, Kai
dc.contributor.authorRuhnke, Markus
dc.date.accessioned2013-05-21T13:19:48Z
dc.date.available2013-05-21T13:19:48Z
dc.date.issued2012-05
dc.identifier.citationInfluence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis. 2012, 50 (4):421-6 Med. Mycol.en_GB
dc.identifier.issn1460-2709
dc.identifier.pmid21939345
dc.identifier.doi10.3109/13693786.2011.608730
dc.identifier.urihttp://hdl.handle.net/10147/292545
dc.description.abstractThe effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the presence of DOX in the chequerboard assay with FIC indices suggesting an antagonistic effect. Gene expression analyses showed an overexpression of CdCDR2. Hence, DOX was found to have an impact on resistance mechanisms in C. dubliniensis isolates.
dc.language.isoenen
dc.publisherMedical mycology : official publication of the International Society for Human and Animal Mycologyen_GB
dc.rightsArchived with thanks to Medical mycology : official publication of the International Society for Human and Animal Mycologyen_GB
dc.subject.meshAntifungal Agents
dc.subject.meshBiological Transport, Active
dc.subject.meshCandida
dc.subject.meshDoxorubicin
dc.subject.meshFluconazole
dc.subject.meshGene Expression
dc.subject.meshGene Expression Profiling
dc.subject.meshHumans
dc.subject.meshMicrobial Sensitivity Tests
dc.titleInfluence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis.en_GB
dc.typeArticleen
dc.contributor.departmentCharité-Universitätsmedizin Berlin, Charit Campus Mitte, Medical Department, Division of Oncology and Haematology, Berlin, Germany. bettina_schulz@arcor.deen_GB
dc.identifier.journalMedical mycology : official publication of the International Society for Human and Animal Mycologyen_GB
dc.description.provinceLeinsteren
html.description.abstractThe effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the presence of DOX in the chequerboard assay with FIC indices suggesting an antagonistic effect. Gene expression analyses showed an overexpression of CdCDR2. Hence, DOX was found to have an impact on resistance mechanisms in C. dubliniensis isolates.


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