Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis.
Affiliation
Charité-Universitätsmedizin Berlin, Charit Campus Mitte, Medical Department, Division of Oncology and Haematology, Berlin, Germany. bettina_schulz@arcor.deIssue Date
2012-05MeSH
Antifungal AgentsBiological Transport, Active
Candida
Doxorubicin
Fluconazole
Gene Expression
Gene Expression Profiling
Humans
Microbial Sensitivity Tests
Metadata
Show full item recordCitation
Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis. 2012, 50 (4):421-6 Med. Mycol.Publisher
Medical mycology : official publication of the International Society for Human and Animal MycologyJournal
Medical mycology : official publication of the International Society for Human and Animal MycologyDOI
10.3109/13693786.2011.608730PubMed ID
21939345Abstract
The effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the presence of DOX in the chequerboard assay with FIC indices suggesting an antagonistic effect. Gene expression analyses showed an overexpression of CdCDR2. Hence, DOX was found to have an impact on resistance mechanisms in C. dubliniensis isolates.Item Type
ArticleLanguage
enISSN
1460-2709ae974a485f413a2113503eed53cd6c53
10.3109/13693786.2011.608730