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    Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis.

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    Authors
    Schulz, Bettina
    Knobloch, Mathias
    Moran, Gary P
    Weber, Kai
    Ruhnke, Markus
    Affiliation
    Charité-Universitätsmedizin Berlin, Charit Campus Mitte, Medical Department, Division of Oncology and Haematology, Berlin, Germany. bettina_schulz@arcor.de
    Issue Date
    2012-05
    MeSH
    Antifungal Agents
    Biological Transport, Active
    Candida
    Doxorubicin
    Fluconazole
    Gene Expression
    Gene Expression Profiling
    Humans
    Microbial Sensitivity Tests
    
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    Show full item record
    Citation
    Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis. 2012, 50 (4):421-6 Med. Mycol.
    Publisher
    Medical mycology : official publication of the International Society for Human and Animal Mycology
    Journal
    Medical mycology : official publication of the International Society for Human and Animal Mycology
    URI
    http://hdl.handle.net/10147/292545
    DOI
    10.3109/13693786.2011.608730
    PubMed ID
    21939345
    Abstract
    The effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the presence of DOX in the chequerboard assay with FIC indices suggesting an antagonistic effect. Gene expression analyses showed an overexpression of CdCDR2. Hence, DOX was found to have an impact on resistance mechanisms in C. dubliniensis isolates.
    Item Type
    Article
    Language
    en
    ISSN
    1460-2709
    ae974a485f413a2113503eed53cd6c53
    10.3109/13693786.2011.608730
    Scopus Count
    Collections
    Dublin Dental University Hospital

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