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dc.contributor.authorBrennan, Gráinne I
dc.contributor.authorShore, Anna C
dc.contributor.authorCorcoran, Suzanne
dc.contributor.authorTecklenborg, Sarah
dc.contributor.authorColeman, David C
dc.contributor.authorO'Connell, Brian
dc.date.accessioned2013-05-21T13:20:15Z
dc.date.available2013-05-21T13:20:15Z
dc.date.issued2012-03
dc.identifier.citationEmergence of hospital- and community-associated panton-valentine leukocidin-positive methicillin-resistant Staphylococcus aureus genotype ST772-MRSA-V in Ireland and detailed investigation of an ST772-MRSA-V cluster in a neonatal intensive care unit. 2012, 50 (3):841-7 J. Clin. Microbiol.en_GB
dc.identifier.issn1098-660X
dc.identifier.pmid22189119
dc.identifier.doi10.1128/JCM.06354-11
dc.identifier.urihttp://hdl.handle.net/10147/292534
dc.description.abstractSequence type 22 (ST22) methicillin-resistant Staphylococcus aureus (MRSA) harboring staphylococcal cassette chromosome mec (SCCmec) IV (ST22-MRSA-IV) has predominated in Irish hospitals since the late 1990s. Six distinct clones of community-associated MRSA (CA-MRSA) have also been identified in Ireland. A new strain of CA-MRSA, ST772-MRSA-V, has recently emerged and become widespread in India and has spread into hospitals. In the present study, highly similar MRSA isolates were recovered from seven colonized neonates in a neonatal intensive care unit (NICU) in a maternity hospital in Ireland during 2010 and 2011, two colonized NICU staff, one of their colonized children, and a NICU environmental site. The isolates exhibited multiantibiotic resistance, spa type t657, and were assigned to ST772-MRSA-V by DNA microarray profiling. All isolates encoded resistance to macrolides [msr(A) and mpb(BM)] and aminoglycosides (aacA-aphD and aphA3) and harbored the Panton-Valentine leukocidin toxin genes (lukF-PV and lukS-PV), enterotoxin genes (sea, sec, sel, and egc), and one of the immune evasion complex genes (scn). One of the NICU staff colonized by ST772-MRSA-V was identified as the probable index case, based on recent travel to India. Seven additional hospital and CA-ST772-MRSA-V isolates recovered from skin and soft tissue infections in Ireland between 2009 and 2011 exhibiting highly similar phenotypic and genotypic characteristics to the NICU isolates were also identified. The clinical details of four of these patients revealed connections with India through ethnic background or travel. Our study indicates that hospital-acquired and CA-ST772-MRSA-V is currently emerging in Ireland and may have been imported from India on several occasions.
dc.language.isoenen
dc.rightsArchived with thanks to Journal of clinical microbiologyen_GB
dc.subject.meshAdult
dc.subject.meshAged, 80 and over
dc.subject.meshBacterial Toxins
dc.subject.meshChild
dc.subject.meshCommunity-Acquired Infections
dc.subject.meshCross Infection
dc.subject.meshDrug Resistance, Multiple, Bacterial
dc.subject.meshExotoxins
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshIntensive Care, Neonatal
dc.subject.meshIreland
dc.subject.meshLeukocidins
dc.subject.meshMethicillin-Resistant Staphylococcus aureus
dc.subject.meshMicroarray Analysis
dc.subject.meshMolecular Epidemiology
dc.subject.meshMolecular Typing
dc.subject.meshStaphylococcal Infections
dc.subject.meshVirulence Factors
dc.subject.meshYoung Adult
dc.titleEmergence of hospital- and community-associated panton-valentine leukocidin-positive methicillin-resistant Staphylococcus aureus genotype ST772-MRSA-V in Ireland and detailed investigation of an ST772-MRSA-V cluster in a neonatal intensive care unit.en_GB
dc.typeArticleen
dc.contributor.departmentNational MRSA Reference Laboratory, St. James’s Hospital, Dublin, Ireland. gbrennan@stjames.ieen_GB
dc.identifier.journalJournal of clinical microbiologyen_GB
dc.description.provinceLeinsteren
refterms.dateFOA2018-08-23T05:21:36Z
html.description.abstractSequence type 22 (ST22) methicillin-resistant Staphylococcus aureus (MRSA) harboring staphylococcal cassette chromosome mec (SCCmec) IV (ST22-MRSA-IV) has predominated in Irish hospitals since the late 1990s. Six distinct clones of community-associated MRSA (CA-MRSA) have also been identified in Ireland. A new strain of CA-MRSA, ST772-MRSA-V, has recently emerged and become widespread in India and has spread into hospitals. In the present study, highly similar MRSA isolates were recovered from seven colonized neonates in a neonatal intensive care unit (NICU) in a maternity hospital in Ireland during 2010 and 2011, two colonized NICU staff, one of their colonized children, and a NICU environmental site. The isolates exhibited multiantibiotic resistance, spa type t657, and were assigned to ST772-MRSA-V by DNA microarray profiling. All isolates encoded resistance to macrolides [msr(A) and mpb(BM)] and aminoglycosides (aacA-aphD and aphA3) and harbored the Panton-Valentine leukocidin toxin genes (lukF-PV and lukS-PV), enterotoxin genes (sea, sec, sel, and egc), and one of the immune evasion complex genes (scn). One of the NICU staff colonized by ST772-MRSA-V was identified as the probable index case, based on recent travel to India. Seven additional hospital and CA-ST772-MRSA-V isolates recovered from skin and soft tissue infections in Ireland between 2009 and 2011 exhibiting highly similar phenotypic and genotypic characteristics to the NICU isolates were also identified. The clinical details of four of these patients revealed connections with India through ethnic background or travel. Our study indicates that hospital-acquired and CA-ST772-MRSA-V is currently emerging in Ireland and may have been imported from India on several occasions.


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