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    Emergence of hospital- and community-associated panton-valentine leukocidin-positive methicillin-resistant Staphylococcus aureus genotype ST772-MRSA-V in Ireland and detailed investigation of an ST772-MRSA-V cluster in a neonatal intensive care unit.

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    Authors
    Brennan, Gráinne I
    Shore, Anna C
    Corcoran, Suzanne
    Tecklenborg, Sarah
    Coleman, David C
    O'Connell, Brian
    Affiliation
    National MRSA Reference Laboratory, St. James’s Hospital, Dublin, Ireland. gbrennan@stjames.ie
    Issue Date
    2012-03
    MeSH
    Adult
    Aged, 80 and over
    Bacterial Toxins
    Child
    Community-Acquired Infections
    Cross Infection
    Drug Resistance, Multiple, Bacterial
    Exotoxins
    Genotype
    Humans
    Infant
    Infant, Newborn
    Intensive Care, Neonatal
    Ireland
    Leukocidins
    Methicillin-Resistant Staphylococcus aureus
    Microarray Analysis
    Molecular Epidemiology
    Molecular Typing
    Staphylococcal Infections
    Virulence Factors
    Young Adult
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    Citation
    Emergence of hospital- and community-associated panton-valentine leukocidin-positive methicillin-resistant Staphylococcus aureus genotype ST772-MRSA-V in Ireland and detailed investigation of an ST772-MRSA-V cluster in a neonatal intensive care unit. 2012, 50 (3):841-7 J. Clin. Microbiol.
    Journal
    Journal of clinical microbiology
    URI
    http://hdl.handle.net/10147/292534
    DOI
    10.1128/JCM.06354-11
    PubMed ID
    22189119
    Abstract
    Sequence type 22 (ST22) methicillin-resistant Staphylococcus aureus (MRSA) harboring staphylococcal cassette chromosome mec (SCCmec) IV (ST22-MRSA-IV) has predominated in Irish hospitals since the late 1990s. Six distinct clones of community-associated MRSA (CA-MRSA) have also been identified in Ireland. A new strain of CA-MRSA, ST772-MRSA-V, has recently emerged and become widespread in India and has spread into hospitals. In the present study, highly similar MRSA isolates were recovered from seven colonized neonates in a neonatal intensive care unit (NICU) in a maternity hospital in Ireland during 2010 and 2011, two colonized NICU staff, one of their colonized children, and a NICU environmental site. The isolates exhibited multiantibiotic resistance, spa type t657, and were assigned to ST772-MRSA-V by DNA microarray profiling. All isolates encoded resistance to macrolides [msr(A) and mpb(BM)] and aminoglycosides (aacA-aphD and aphA3) and harbored the Panton-Valentine leukocidin toxin genes (lukF-PV and lukS-PV), enterotoxin genes (sea, sec, sel, and egc), and one of the immune evasion complex genes (scn). One of the NICU staff colonized by ST772-MRSA-V was identified as the probable index case, based on recent travel to India. Seven additional hospital and CA-ST772-MRSA-V isolates recovered from skin and soft tissue infections in Ireland between 2009 and 2011 exhibiting highly similar phenotypic and genotypic characteristics to the NICU isolates were also identified. The clinical details of four of these patients revealed connections with India through ethnic background or travel. Our study indicates that hospital-acquired and CA-ST772-MRSA-V is currently emerging in Ireland and may have been imported from India on several occasions.
    Item Type
    Article
    Language
    en
    ISSN
    1098-660X
    ae974a485f413a2113503eed53cd6c53
    10.1128/JCM.06354-11
    Scopus Count
    Collections
    Dublin Dental University Hospital

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