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    Triclosan antagonizes fluconazole activity against Candida albicans.

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    Authors
    Higgins, J
    Pinjon, E
    Oltean, H N
    White, T C
    Kelly, S L
    Martel, C M
    Sullivan, D J
    Coleman, D C
    Moran, G P
    Affiliation
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, University of Dublin, Trinity College Dublin, Lincoln Place, Dublin 2, Ireland.
    Issue Date
    2012-01
    MeSH
    Antifungal Agents
    Candida albicans
    Drug Antagonism
    Fatty Acids
    Fluconazole
    Fungal Proteins
    Hyphae
    Membrane Transport Proteins
    Microbial Sensitivity Tests
    Species Specificity
    Triclosan
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    Citation
    Triclosan antagonizes fluconazole activity against Candida albicans. 2012, 91 (1):65-70 J. Dent. Res.
    Publisher
    Journal of dental research
    Journal
    Journal of dental research
    URI
    http://hdl.handle.net/10147/292497
    DOI
    10.1177/0022034511425046
    PubMed ID
    21972257
    Abstract
    Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, at subinhibitory concentrations (0.5-2 mg/L), triclosan antagonized the activity of fluconazole. Although triclosan induced CDR1 expression in C. albicans, antagonism was still observed in cdr1Δ and cdr2Δ strains. Triclosan did not affect fluconazole uptake or alter total membrane sterol content, but did induce the expression of FAS1 and FAS2, indicating that its mode of action may involve inhibition of fatty acid synthesis, as it does in prokaryotes. However, FAS2 mutants did not exhibit increased susceptibility to triclosan, and overexpression of both FAS1 and FAS2 alleles did not alter triclosan susceptibility. Unexpectedly, the antagonistic effect was specific for C. albicans under hypha-inducing conditions and was absent in the non-filamentous efg1Δ strain. This antagonism may be due to the membranotropic activity of triclosan and the unique composition of hyphal membranes.
    Item Type
    Article
    Language
    en
    ISSN
    1544-0591
    ae974a485f413a2113503eed53cd6c53
    10.1177/0022034511425046
    Scopus Count
    Collections
    Dublin Dental University Hospital

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