Affiliation
Department of Nephrology, Beaumont Hospital, Dublin, Ireland. caroltraynor@physicians.ieIssue Date
2012-12MeSH
AdultComorbidity
Female
Graft Rejection
Graft Survival
Humans
Kidney Transplantation
Living Donors
Male
Retrospective Studies
Risk Factors
Survival Rate
Survivors
Time Factors
Metadata
Show full item recordCitation
Twenty-year survivors of kidney transplantation. 2012, 12 (12):3289-95 Am. J. Transplant.Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsDOI
10.1111/j.1600-6143.2012.04236.xPubMed ID
22947033Abstract
There have been few studies of patients with renal allografts functioning for more than 20 years. We sought to identify clinical factors associated with ultra long-term (>20 year) renal allograft survival and to describe the clinical features of these patients. We performed a retrospective analysis of the Irish Renal Transplant Database and included 1174 transplants in 1002 patients. There were 255 (21.74%) patients with graft function for 20 years or more. Multivariate analysis identified recipient age (HR 1.01, CI 1.01-1.02), gender (male HR 1.25, CI 1.08-1.45), acute rejection (HR 1.26, CI 1.09-1.45) and transplant type (living related donor vs. deceased donor) (HR 0.52, CI 0.40-0.66) as significantly associated with long-term graft loss. Median serum creatinine was 115 μmol/L. The 5-year graft survival in 20-year survivors was 74.7%. The mean age at death was 62.7 years (±10.6). The most common causes of death were cardiovascular disease and malignancy. The two major causes of graft loss were death (with function) and interstitial fibrosis/tubular atrophy. Comorbidities included skin cancer (36.1%), coronary heart disease (17.3%) and other malignancies (14.5%). This study identifies factors associated with long-term allograft survival and a high rate of morbidity and early mortality in long-term transplant recipients.Item Type
ArticleLanguage
enISSN
1600-6143ae974a485f413a2113503eed53cd6c53
10.1111/j.1600-6143.2012.04236.x
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