Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine.
dc.contributor.author | Olivieri, Aldo | |
dc.contributor.author | Tipton, Keith F | |
dc.contributor.author | O'Sullivan, Jeff | |
dc.date.accessioned | 2013-05-14T11:43:46Z | |
dc.date.available | 2013-05-14T11:43:46Z | |
dc.date.issued | 2012-04 | |
dc.identifier.citation | Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine. 2012, 1820 (4):482-7 Biochim. Biophys. Acta | en_GB |
dc.identifier.issn | 0006-3002 | |
dc.identifier.pmid | 22202180 | |
dc.identifier.doi | 10.1016/j.bbagen.2011.12.009 | |
dc.identifier.uri | http://hdl.handle.net/10147/291083 | |
dc.description.abstract | Primary-amine oxidase (PrAO) catalyzes the oxidative deamination of endogenous and exogenous primary amines and also functions, in some tissues, as an inflammation-inducible endothelial factor, known as vascular adhesion protein-1. VAP-1 mediates the slow rolling and adhesion of lymphocytes to endothelial cells in a number of inflammatory conditions, including inflammation of the synovium. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to Biochimica et biophysica acta | en_GB |
dc.subject.mesh | Amine Oxidase (Copper-Containing) | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Cattle | |
dc.subject.mesh | Cell Adhesion | |
dc.subject.mesh | Deamination | |
dc.subject.mesh | Endothelial Cells | |
dc.subject.mesh | Glucosamine | |
dc.subject.mesh | Hydrogen Peroxide | |
dc.subject.mesh | Leukocyte Rolling | |
dc.subject.mesh | Lymphocytes | |
dc.subject.mesh | Osteoarthritis | |
dc.subject.mesh | Oxidation-Reduction | |
dc.title | Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine. | en_GB |
dc.type | Article | en |
dc.contributor.department | School of Biochemistry and Immunology, Trinity College Dublin, Ireland. oliviera@tcd.ie | en_GB |
dc.identifier.journal | Biochimica et biophysica acta | en_GB |
dc.description.province | Leinster | en |
html.description.abstract | Primary-amine oxidase (PrAO) catalyzes the oxidative deamination of endogenous and exogenous primary amines and also functions, in some tissues, as an inflammation-inducible endothelial factor, known as vascular adhesion protein-1. VAP-1 mediates the slow rolling and adhesion of lymphocytes to endothelial cells in a number of inflammatory conditions, including inflammation of the synovium. |