Occupation and risk of upper aerodigestive tract cancer: the ARCAGE study.
Authors
Richiardi, LorenzoCorbin, Marine
Marron, Manuela
Ahrens, Wolfgang
Pohlabeln, Hermann
Lagiou, Pagona
Minaki, Ploumitsa
Agudo, Antonio
Castellsague, Xavier
Slamova, Alena
Schejbalova, Miriam
Kjaerheim, Kristina
Barzan, Luigi
Talamini, Renato
Macfarlane, Gary J
Macfarlane, Tatiana V
Canova, Cristina
Simonato, Lorenzo
Conway, David I
McKinney, Patricia A
Sneddon, Linda
Thomson, Peter
Znaor, Ariana
Healy, Claire M
McCartan, Bernard E
Benhamou, Simone
Bouchardy, Christine
Hashibe, Mia
Brennan, Paul
Merletti, Franco
Affiliation
University of Turin, Turin, Italy. lorenzo.richiardi@unito.itIssue Date
2012-05-15MeSH
AdultAged
Case-Control Studies
Construction Industry
Esophageal Neoplasms
Europe
Female
Humans
Laryngeal Neoplasms
Male
Middle Aged
Mouth Neoplasms
Neoplasms
Occupations
Pharyngeal Neoplasms
Risk
Risk Factors
Metadata
Show full item recordCitation
Occupation and risk of upper aerodigestive tract cancer: the ARCAGE study. 2012, 130 (10):2397-406 Int. J. CancerJournal
International journal of cancer. Journal international du cancerDOI
10.1002/ijc.26237PubMed ID
21671472Abstract
We investigated the association between occupational history and upper aerodigestive tract (UADT) cancer risk in the ARCAGE European case-control study. The study included 1,851 patients with incident cancer of the oral cavity, oropharynx, hypopharynx, larynx or esophagus and 1,949 controls. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ever employment in 283 occupations and 172 industries, adjusting for smoking and alcohol. Men (1,457 cases) and women (394 cases) were analyzed separately and we incorporated a semi-Bayes adjustment approach for multiple comparisons. Among men, we found increased risks for occupational categories previously reported to be associated with at least one type of UADT cancer, including painters (OR = 1.74, 95% CI: 1.01-3.00), bricklayers (1.58, 1.05-2.37), workers employed in the erection of roofs and frames (2.62, 1.08-6.36), reinforced concreters (3.46, 1.11-10.8), dockers (2.91, 1.05-8.05) and workers employed in the construction of roads (3.03, 1.23-7.46), general construction of buildings (1.44, 1.12-1.85) and cargo handling (2.60, 1.17-5.75). With the exception of the first three categories, risks both increased when restricting to long duration of employment and remained elevated after semi-Bayes adjustment. Increased risks were also found for loggers (3.56, 1.20-10.5) and cattle and dairy farming (3.60, 1.15-11.2). Among women, there was no clear evidence of increased risks of UADT cancer in association with occupations or industrial activities. This study provides evidence of an association between some occupational categories and UADT cancer risk among men. The most consistent findings, also supported by previous studies, were obtained for specific workers employed in the construction industry.Item Type
ArticleLanguage
enISSN
1097-0215ae974a485f413a2113503eed53cd6c53
10.1002/ijc.26237
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