Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method.
Authors
Johansson, MattiasRoberts, Angus
Chen, Dan
Li, Yaoyong
Delahaye-Sourdeix, Manon
Aswani, Niraj
Greenwood, Mark A
Benhamou, Simone
Lagiou, Pagona
Holcátová, Ivana
Richiardi, Lorenzo
Kjaerheim, Kristina
Agudo, Antonio
Castellsagué, Xavier
Macfarlane, Tatiana V
Barzan, Luigi
Canova, Cristina
Thakker, Nalin S
Conway, David I
Znaor, Ariana
Healy, Claire M
Ahrens, Wolfgang
Zaridze, David
Szeszenia-Dabrowska, Neonilia
Lissowska, Jolanta
Fabiánová, Eleonóra
Mates, Ioan Nicolae
Bencko, Vladimir
Foretova, Lenka
Janout, Vladimir
Curado, Maria Paula
Koifman, Sergio
Menezes, Ana
Wünsch-Filho, Victor
Eluf-Neto, Jose
Boffetta, Paolo
Franceschi, Silvia
Herrero, Rolando
Fernandez Garrote, Leticia
Talamini, Renato
Boccia, Stefania
Galan, Pilar
Vatten, Lars
Thomson, Peter
Zelenika, Diana
Lathrop, Mark
Byrnes, Graham
Cunningham, Hamish
Brennan, Paul
Wakefield, Jon
McKay, James D
Affiliation
Section of Genetics, International Agency for Research on Cancer (IARC), Lyon, France. johanssonm@iarc.frIssue Date
2012MeSH
Bayes TheoremChromosomes, Human, Pair 4
Computational Biology
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Internet
Lung Neoplasms
Mouth Neoplasms
Polymorphism, Single Nucleotide
Reproducibility of Results
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Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method. 2012, 7 (5):e36888 PLoS ONEJournal
PloS oneDOI
10.1371/journal.pone.0036888PubMed ID
22662130Abstract
Genome-wide association studies (GWAS) require large sample sizes to obtain adequate statistical power, but it may be possible to increase the power by incorporating complementary data. In this study we investigated the feasibility of automatically retrieving information from the medical literature and leveraging this information in GWAS.Item Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0036888
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