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dc.contributor.authorCheallaigh, Clíona Ní
dc.contributor.authorFitzgerald, Ian
dc.contributor.authorGrace, Jacinta
dc.contributor.authorSingh, Gurmit Jagjit
dc.contributor.authorEl-Eraki, Nahla
dc.contributor.authorGibbons, Noel
dc.contributor.authorKeane, Joseph
dc.contributor.authorRogers, Thomas R
dc.contributor.authorClarke, Susan
dc.contributor.authorBergin, Colm
dc.date.accessioned2013-04-25T10:39:09Z
dc.date.available2013-04-25T10:39:09Z
dc.date.issued2013-01
dc.identifier.citationInterferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country. 2013, 8 (1):e53330 PLoS ONEen_GB
dc.identifier.issn1932-6203
dc.identifier.pmid23382842
dc.identifier.doi10.1371/journal.pone.0053330
dc.identifier.urihttp://hdl.handle.net/10147/285032
dc.description.abstractInterferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting.
dc.language.isoenen
dc.publisherPloS oneen_GB
dc.rightsArchived with thanks to PloS oneen_GB
dc.titleInterferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Genito-Urinary Medicine and Infectious Diseases, St James's Hospital, Dublin, Ireland. nicheacm@tcd.ieen_GB
dc.identifier.journalPloS oneen_GB
dc.description.provinceLeinsteren
refterms.dateFOA2018-08-23T04:48:08Z
html.description.abstractInterferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting.


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