Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country.
dc.contributor.author | Cheallaigh, Clíona Ní | |
dc.contributor.author | Fitzgerald, Ian | |
dc.contributor.author | Grace, Jacinta | |
dc.contributor.author | Singh, Gurmit Jagjit | |
dc.contributor.author | El-Eraki, Nahla | |
dc.contributor.author | Gibbons, Noel | |
dc.contributor.author | Keane, Joseph | |
dc.contributor.author | Rogers, Thomas R | |
dc.contributor.author | Clarke, Susan | |
dc.contributor.author | Bergin, Colm | |
dc.date.accessioned | 2013-04-25T10:39:09Z | |
dc.date.available | 2013-04-25T10:39:09Z | |
dc.date.issued | 2013-01 | |
dc.identifier.citation | Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country. 2013, 8 (1):e53330 PLoS ONE | en_GB |
dc.identifier.issn | 1932-6203 | |
dc.identifier.pmid | 23382842 | |
dc.identifier.doi | 10.1371/journal.pone.0053330 | |
dc.identifier.uri | http://hdl.handle.net/10147/285032 | |
dc.description.abstract | Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting. | |
dc.language.iso | en | en |
dc.publisher | PloS one | en_GB |
dc.rights | Archived with thanks to PloS one | en_GB |
dc.title | Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country. | en_GB |
dc.type | Article | en |
dc.contributor.department | Department of Genito-Urinary Medicine and Infectious Diseases, St James's Hospital, Dublin, Ireland. nicheacm@tcd.ie | en_GB |
dc.identifier.journal | PloS one | en_GB |
dc.description.province | Leinster | en |
refterms.dateFOA | 2018-08-23T04:48:08Z | |
html.description.abstract | Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting. |