Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country.
AuthorsCheallaigh, Clíona Ní
Singh, Gurmit Jagjit
Rogers, Thomas R
AffiliationDepartment of Genito-Urinary Medicine and Infectious Diseases, St James's Hospital, Dublin, Ireland. email@example.com
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CitationInterferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country. 2013, 8 (1):e53330 PLoS ONE
AbstractInterferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting.