The SGBS cell strain as a model for the in vitro study of obesity and cancer.
Authors
Allott, Emma HOliver, Elizabeth
Lysaght, Joanne
Gray, Steven G
Reynolds, John V
Roche, Helen M
Pidgeon, Graham P
Affiliation
Department of Surgery, Trinity Centre for Health Sciences, Institute of Molecular Medicine, St James' Hospital, Trinity College Dublin, Ireland.Issue Date
2012-10MeSH
3T3-L1 CellsAdipocytes
Adipogenesis
Animals
Arrhythmias, Cardiac
Cell Line
Gene Expression Profiling
Gene Expression Regulation
Genetic Diseases, X-Linked
Gigantism
Heart Defects, Congenital
Humans
Intellectual Disability
Mice
Microarray Analysis
Models, Theoretical
Neoplasms
Obesity
Primary Cell Culture
Metadata
Show full item recordCitation
The SGBS cell strain as a model for the in vitro study of obesity and cancer. 2012, 14 (10):774-82 Clin Transl OncolJournal
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of MexicoDOI
10.1007/s12094-012-0863-6PubMed ID
22855155Abstract
The murine adipocyte cell line 3T3-L1 is well characterised and used widely, while the human pre-adipocyte cell strain, Simpson-Golabi-Behmel Syndrome (SGBS), requires validation for use in human studies. Obesity is currently estimated to account for up to 41 % of the worldwide cancer burden. A human in vitro model system is required to elucidate the molecular mechanisms for this poorly understood association. This work investigates the relevance of the SGBS cell strain for obesity and cancer research in humans.Item Type
ArticleLanguage
enISSN
1699-3055ae974a485f413a2113503eed53cd6c53
10.1007/s12094-012-0863-6
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