Is there an Association between Peripheral Immune Markers and Structural/Functional Neuroimaging Findings?
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Affiliation
Department of Psychiatry, Trinity College Institute of Neuroscience, Trinity College Dublin; Adelaide and Meath incorporating the National's Children Hospital Dublin; St. James's Hospital Dublin. Electronic address: frodlt@tcd.ie.Issue Date
2013-01-10
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Is there an Association between Peripheral Immune Markers and Structural/Functional Neuroimaging Findings? 2013: Prog. Neuropsychopharmacol. Biol. PsychiatryJournal
Progress in neuro-psychopharmacology & biological psychiatryDOI
10.1016/j.pnpbp.2012.12.013PubMed ID
23313563Abstract
OBJECTIVES: There is mounting evidence that inflammatory processes play a key role in emotional as well as cognitive dysfunctions. In this context, research employing magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MR spectroscopy) suggests a possible link between structural/functional anomalies in the brain and an increase of circulating inflammation markers. The present paper reviews this research, with particular focus on major depressive disorder (MDD), cognitive impairment in older adults, Alzheimer's disease (AD) and schizophrenia. RESULTS: In MDD, cognitive impairment and AD, inflammatory processes have been found to be associated with both structural and functional anomalies, perhaps under the influence of environmental stress. Not enough research can suggest similar considerations in schizophrenia, although studies in mice and non-human primates support the belief that inflammatory responses generated during pregnancy can affect brain development and contribute to the etiology of schizophrenia. CONCLUSIONS: The present review suggests a link between inflammatory processes and MRI detected anomalies in the brain of individuals with MDD, older adults with cognitive impairment as well as of individuals with AD and schizophrenia.Item Type
ArticleLanguage
enISSN
1878-4216ae974a485f413a2113503eed53cd6c53
10.1016/j.pnpbp.2012.12.013