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dc.contributor.authorRenwick, Laoise
dc.contributor.authorJackson, Deirdre
dc.contributor.authorFoley, Sharon
dc.contributor.authorOwens, Elizabeth
dc.contributor.authorRamperti, Nicolas
dc.contributor.authorBehan, Caragh
dc.contributor.authorAnwar, Mansoor
dc.contributor.authorKinsella, Anthony
dc.contributor.authorTurner, Niall
dc.contributor.authorClarke, Mary
dc.contributor.authorO'Callaghan, Eadbhard
dc.date.accessioned2013-01-15T15:52:13Z
dc.date.available2013-01-15T15:52:13Z
dc.date.issued2012-07
dc.identifier.citationDepression and quality of life in first-episode psychosis. 2012, 53 (5):451-5 Compr Psychiatryen_GB
dc.identifier.issn1532-8384
dc.identifier.pmid21871616
dc.identifier.doi10.1016/j.comppsych.2011.07.003
dc.identifier.urihttp://hdl.handle.net/10147/265515
dc.descriptionAIM: Quality of life (QOL) has gained recognition as a valid measure of outcome in first-episode psychosis (FEP). This study aimed to determine the influence of specific groups of depressive symptoms on separate domains of subjectively appraised QOL. METHODS: We assessed 208 individuals with first-episode non-affective psychosis using measures of diagnosis (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), symptoms (Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning), insight (Birchwood Scale), duration of untreated psychosis (Beiser Scale), and QOL World Health Organisation Quality of Life Instrument (WHOQOL-Bref). We used multiple regression to determine the contribution of depressive symptoms to QOL domains while controlling for socio-demographic and other clinical characteristics. RESULTS: There were complete data for 146 individuals with FEP. Quality-of-life domains were consistently predicted by depressive symptoms including depressive mood and hopelessness rather than biological symptoms of depression with those experiencing more depressive symptoms reporting worse QOL. Those who were treated as in-patients reported improved QOL, and hospitalization was an independent predictor of most QOL domains. In-patients displayed greater levels of positive symptoms with those involuntarily detained displaying greater levels of bizarre behavior, thought disorder, and delusions. CONCLUSIONS: These findings suggest that QOL is heavily influenced by depressive symptoms at initial presentation; however, as QOL domains are also influenced by admission status with in-patients being more symptomatic in terms of positive symptoms, subjective QOL assessment may be compromised during the acute phase of illness by both positive and depressive symptom severity.en_GB
dc.description.abstractQuality of life (QOL) has gained recognition as a valid measure of outcome in first-episode psychosis (FEP). This study aimed to determine the influence of specific groups of depressive symptoms on separate domains of subjectively appraised QOL.
dc.description.abstractWe assessed 208 individuals with first-episode non-affective psychosis using measures of diagnosis (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), symptoms (Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning), insight (Birchwood Scale), duration of untreated psychosis (Beiser Scale), and QOL World Health Organisation Quality of Life Instrument (WHOQOL-Bref). We used multiple regression to determine the contribution of depressive symptoms to QOL domains while controlling for socio-demographic and other clinical characteristics.
dc.description.abstractThere were complete data for 146 individuals with FEP. Quality-of-life domains were consistently predicted by depressive symptoms including depressive mood and hopelessness rather than biological symptoms of depression with those experiencing more depressive symptoms reporting worse QOL. Those who were treated as in-patients reported improved QOL, and hospitalization was an independent predictor of most QOL domains. In-patients displayed greater levels of positive symptoms with those involuntarily detained displaying greater levels of bizarre behavior, thought disorder, and delusions.
dc.description.abstractThese findings suggest that QOL is heavily influenced by depressive symptoms at initial presentation; however, as QOL domains are also influenced by admission status with in-patients being more symptomatic in terms of positive symptoms, subjective QOL assessment may be compromised during the acute phase of illness by both positive and depressive symptom severity.
dc.language.isoenen
dc.rightsArchived with thanks to Comprehensive psychiatryen_GB
dc.subjectDEPRESSIONen_GB
dc.subjectPSYCHOTIC DISORDERSen_GB
dc.subjectEPIDEMIOLOGYen_GB
dc.subjectPSYCHOLOGYen_GB
dc.subjectSCHIZOPHRENIAen_GB
dc.subjectCOMORBIDITYen_GB
dc.subjectIRELANDen_GB
dc.subjectQUALITY OF LIFEen_GB
dc.subjectREGRESSION ANALYSISen_GB
dc.subjectCROSS-SECTIONAL STUDIESen_GB
dc.subject.meshAdult
dc.subject.meshComorbidity
dc.subject.meshCross-Sectional Studies
dc.subject.meshDepression
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIreland
dc.subject.meshMale
dc.subject.meshPsychotic Disorders
dc.subject.meshQuality of Life
dc.subject.meshRegression Analysis
dc.subject.meshSchizophrenia
dc.subject.meshSchizophrenic Psychology
dc.titleDepression and quality of life in first-episode psychosis.en_GB
dc.typeArticleen
dc.contributor.departmentDETECT Early Psychosis Service, Dublin, Ireland. laoise.renwick@detect.ieen_GB
dc.identifier.journalComprehensive psychiatryen_GB
html.description.abstractQuality of life (QOL) has gained recognition as a valid measure of outcome in first-episode psychosis (FEP). This study aimed to determine the influence of specific groups of depressive symptoms on separate domains of subjectively appraised QOL.
html.description.abstractWe assessed 208 individuals with first-episode non-affective psychosis using measures of diagnosis (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), symptoms (Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning), insight (Birchwood Scale), duration of untreated psychosis (Beiser Scale), and QOL World Health Organisation Quality of Life Instrument (WHOQOL-Bref). We used multiple regression to determine the contribution of depressive symptoms to QOL domains while controlling for socio-demographic and other clinical characteristics.
html.description.abstractThere were complete data for 146 individuals with FEP. Quality-of-life domains were consistently predicted by depressive symptoms including depressive mood and hopelessness rather than biological symptoms of depression with those experiencing more depressive symptoms reporting worse QOL. Those who were treated as in-patients reported improved QOL, and hospitalization was an independent predictor of most QOL domains. In-patients displayed greater levels of positive symptoms with those involuntarily detained displaying greater levels of bizarre behavior, thought disorder, and delusions.
html.description.abstractThese findings suggest that QOL is heavily influenced by depressive symptoms at initial presentation; however, as QOL domains are also influenced by admission status with in-patients being more symptomatic in terms of positive symptoms, subjective QOL assessment may be compromised during the acute phase of illness by both positive and depressive symptom severity.


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