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Authors
Renwick, LaoiseJackson, Deirdre
Foley, Sharon
Owens, Elizabeth
Ramperti, Nicolas
Behan, Caragh
Anwar, Mansoor
Kinsella, Anthony
Turner, Niall
Clarke, Mary
O'Callaghan, Eadbhard
Affiliation
DETECT Early Psychosis Service, Dublin, Ireland. laoise.renwick@detect.ieIssue Date
2012-07Keywords
DEPRESSIONPSYCHOTIC DISORDERS
EPIDEMIOLOGY
PSYCHOLOGY
SCHIZOPHRENIA
COMORBIDITY
IRELAND
QUALITY OF LIFE
REGRESSION ANALYSIS
CROSS-SECTIONAL STUDIES
MeSH
AdultComorbidity
Cross-Sectional Studies
Depression
Female
Humans
Ireland
Male
Psychotic Disorders
Quality of Life
Regression Analysis
Schizophrenia
Schizophrenic Psychology
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Depression and quality of life in first-episode psychosis. 2012, 53 (5):451-5 Compr PsychiatryJournal
Comprehensive psychiatryDOI
10.1016/j.comppsych.2011.07.003PubMed ID
21871616Abstract
Quality of life (QOL) has gained recognition as a valid measure of outcome in first-episode psychosis (FEP). This study aimed to determine the influence of specific groups of depressive symptoms on separate domains of subjectively appraised QOL.We assessed 208 individuals with first-episode non-affective psychosis using measures of diagnosis (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), symptoms (Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning), insight (Birchwood Scale), duration of untreated psychosis (Beiser Scale), and QOL World Health Organisation Quality of Life Instrument (WHOQOL-Bref). We used multiple regression to determine the contribution of depressive symptoms to QOL domains while controlling for socio-demographic and other clinical characteristics.
There were complete data for 146 individuals with FEP. Quality-of-life domains were consistently predicted by depressive symptoms including depressive mood and hopelessness rather than biological symptoms of depression with those experiencing more depressive symptoms reporting worse QOL. Those who were treated as in-patients reported improved QOL, and hospitalization was an independent predictor of most QOL domains. In-patients displayed greater levels of positive symptoms with those involuntarily detained displaying greater levels of bizarre behavior, thought disorder, and delusions.
These findings suggest that QOL is heavily influenced by depressive symptoms at initial presentation; however, as QOL domains are also influenced by admission status with in-patients being more symptomatic in terms of positive symptoms, subjective QOL assessment may be compromised during the acute phase of illness by both positive and depressive symptom severity.
Item Type
ArticleLanguage
enISSN
1532-8384ae974a485f413a2113503eed53cd6c53
10.1016/j.comppsych.2011.07.003
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