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    Depression and quality of life in first-episode psychosis.

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    Authors
    Renwick, Laoise
    Jackson, Deirdre
    Foley, Sharon
    Owens, Elizabeth
    Ramperti, Nicolas
    Behan, Caragh
    Anwar, Mansoor
    Kinsella, Anthony
    Turner, Niall
    Clarke, Mary
    O'Callaghan, Eadbhard
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    Affiliation
    DETECT Early Psychosis Service, Dublin, Ireland. laoise.renwick@detect.ie
    Issue Date
    2012-07
    Keywords
    DEPRESSION
    PSYCHOTIC DISORDERS
    EPIDEMIOLOGY
    PSYCHOLOGY
    SCHIZOPHRENIA
    COMORBIDITY
    IRELAND
    QUALITY OF LIFE
    REGRESSION ANALYSIS
    CROSS-SECTIONAL STUDIES
    MeSH
    Adult
    Comorbidity
    Cross-Sectional Studies
    Depression
    Female
    Humans
    Ireland
    Male
    Psychotic Disorders
    Quality of Life
    Regression Analysis
    Schizophrenia
    Schizophrenic Psychology
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    Citation
    Depression and quality of life in first-episode psychosis. 2012, 53 (5):451-5 Compr Psychiatry
    Journal
    Comprehensive psychiatry
    URI
    http://hdl.handle.net/10147/265515
    DOI
    10.1016/j.comppsych.2011.07.003
    PubMed ID
    21871616
    Abstract
    Quality of life (QOL) has gained recognition as a valid measure of outcome in first-episode psychosis (FEP). This study aimed to determine the influence of specific groups of depressive symptoms on separate domains of subjectively appraised QOL.
    We assessed 208 individuals with first-episode non-affective psychosis using measures of diagnosis (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), symptoms (Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning), insight (Birchwood Scale), duration of untreated psychosis (Beiser Scale), and QOL World Health Organisation Quality of Life Instrument (WHOQOL-Bref). We used multiple regression to determine the contribution of depressive symptoms to QOL domains while controlling for socio-demographic and other clinical characteristics.
    There were complete data for 146 individuals with FEP. Quality-of-life domains were consistently predicted by depressive symptoms including depressive mood and hopelessness rather than biological symptoms of depression with those experiencing more depressive symptoms reporting worse QOL. Those who were treated as in-patients reported improved QOL, and hospitalization was an independent predictor of most QOL domains. In-patients displayed greater levels of positive symptoms with those involuntarily detained displaying greater levels of bizarre behavior, thought disorder, and delusions.
    These findings suggest that QOL is heavily influenced by depressive symptoms at initial presentation; however, as QOL domains are also influenced by admission status with in-patients being more symptomatic in terms of positive symptoms, subjective QOL assessment may be compromised during the acute phase of illness by both positive and depressive symptom severity.
    Item Type
    Article
    Language
    en
    ISSN
    1532-8384
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.comppsych.2011.07.003
    Scopus Count
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