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dc.contributor.authorLyne, John
dc.contributor.authorO'Donoghue, Brian
dc.contributor.authorOwens, Elizabeth
dc.contributor.authorRenwick, Laoise
dc.contributor.authorMadigan, Kevin
dc.contributor.authorKinsella, Anthony
dc.contributor.authorClarke, Mary
dc.contributor.authorTurner, Niall
dc.contributor.authorO'Callaghan, Eadbhard
dc.date.accessioned2013-01-15T11:40:53Z
dc.date.available2013-01-15T11:40:53Z
dc.date.issued2012-03
dc.identifier.citationPrevalence of item level negative symptoms in first episode psychosis diagnoses. 2012, 135 (1-3):128-33 Schizophr. Res.en_GB
dc.identifier.issn1573-2509
dc.identifier.pmid22281102
dc.identifier.doi10.1016/j.schres.2012.01.004
dc.identifier.urihttp://hdl.handle.net/10147/265455
dc.descriptionThe relevance of negative symptoms across the diagnostic spectrum of the psychoses remains uncertain. The purpose of this study was to report on prevalence of item and subscale level negative symptoms across the first episode psychosis (FEP) diagnostic spectrum in an epidemiological sample, and to ascertain whether items and subscales were more prevalent in a schizophrenia spectrum diagnoses group compared to an 'all other psychotic diagnoses' group. We measured negative symptoms in 330 patients presenting with FEP using the Scale for Assessment of Negative Symptoms (SANS), and ascertained diagnosis using the Structured Clinical Interview for DSM IV. Prevalence of SANS items and subscales were tabulated across all psychotic diagnoses, and logistic regression analysis determined which items and subscales were predictive of schizophrenia spectrum diagnoses. SANS items were most prevalent in schizophrenia spectrum conditions but frequently presented in other FEP diagnoses, particularly substance induced psychotic disorder and Major Depressive Disorder. Brief psychotic disorder and bipolar disorders had low levels of negative symptoms. SANS items and subscales which significantly predicted schizophrenia spectrum diagnoses, were also frequently present in some of the other psychotic diagnoses. Conclusions: SANS items have high prevalence in FEP, and while commonest in schizophrenia spectrum conditions are not restricted to this diagnostic subgroup.en_GB
dc.description.abstractThe relevance of negative symptoms across the diagnostic spectrum of the psychoses remains uncertain. The purpose of this study was to report on prevalence of item and subscale level negative symptoms across the first episode psychosis (FEP) diagnostic spectrum in an epidemiological sample, and to ascertain whether items and subscales were more prevalent in a schizophrenia spectrum diagnoses group compared to an 'all other psychotic diagnoses' group. We measured negative symptoms in 330 patients presenting with FEP using the Scale for Assessment of Negative Symptoms (SANS), and ascertained diagnosis using the Structured Clinical Interview for DSM IV. Prevalence of SANS items and subscales were tabulated across all psychotic diagnoses, and logistic regression analysis determined which items and subscales were predictive of schizophrenia spectrum diagnoses. SANS items were most prevalent in schizophrenia spectrum conditions but frequently presented in other FEP diagnoses, particularly substance induced psychotic disorder and Major Depressive Disorder. Brief psychotic disorder and bipolar disorders had low levels of negative symptoms. SANS items and subscales which significantly predicted schizophrenia spectrum diagnoses, were also frequently present in some of the other psychotic diagnoses. Conclusions: SANS items have high prevalence in FEP, and while commonest in schizophrenia spectrum conditions are not restricted to this diagnostic subgroup.
dc.language.isoenen
dc.rightsArchived with thanks to Schizophrenia researchen_GB
dc.subjectBIPOLAR DISORDERen_GB
dc.subjectDIAGNOSISen_GB
dc.subjectEPIDEMIOLOGYen_GB
dc.subjectDEPRESSIVE DISORDERen_GB
dc.subjectPSYCHIATRIC STATUS RATING SCALESen_GB
dc.subjectPSYCHOTIC DISORDERSen_GB
dc.subjectPSYCHOSISen_GB
dc.subjectSCHIZOPHRENIAen_GB
dc.subjectIRELANDen_GB
dc.subjectPREVALENCEen_GB
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBipolar Disorder
dc.subject.meshDepressive Disorder, Major
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIreland
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPrevalence
dc.subject.meshPsychiatric Status Rating Scales
dc.subject.meshPsychotic Disorders
dc.subject.meshRetrospective Studies
dc.subject.meshSchizophrenia
dc.subject.meshSchizophrenia, Paranoid
dc.subject.meshSeverity of Illness Index
dc.subject.meshYoung Adult
dc.titlePrevalence of item level negative symptoms in first episode psychosis diagnoses.en_GB
dc.typeArticleen
dc.contributor.departmentDETECT Services, Avila House, Block 5 Blackrock Business Park, Blackrock, Co Dublin, Ireland. johnlyne@mail.comen_GB
dc.identifier.journalSchizophrenia researchen_GB
html.description.abstractThe relevance of negative symptoms across the diagnostic spectrum of the psychoses remains uncertain. The purpose of this study was to report on prevalence of item and subscale level negative symptoms across the first episode psychosis (FEP) diagnostic spectrum in an epidemiological sample, and to ascertain whether items and subscales were more prevalent in a schizophrenia spectrum diagnoses group compared to an 'all other psychotic diagnoses' group. We measured negative symptoms in 330 patients presenting with FEP using the Scale for Assessment of Negative Symptoms (SANS), and ascertained diagnosis using the Structured Clinical Interview for DSM IV. Prevalence of SANS items and subscales were tabulated across all psychotic diagnoses, and logistic regression analysis determined which items and subscales were predictive of schizophrenia spectrum diagnoses. SANS items were most prevalent in schizophrenia spectrum conditions but frequently presented in other FEP diagnoses, particularly substance induced psychotic disorder and Major Depressive Disorder. Brief psychotic disorder and bipolar disorders had low levels of negative symptoms. SANS items and subscales which significantly predicted schizophrenia spectrum diagnoses, were also frequently present in some of the other psychotic diagnoses. Conclusions: SANS items have high prevalence in FEP, and while commonest in schizophrenia spectrum conditions are not restricted to this diagnostic subgroup.


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