Prevalence of item level negative symptoms in first episode psychosis diagnoses.
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Authors
Lyne, JohnO'Donoghue, Brian
Owens, Elizabeth
Renwick, Laoise
Madigan, Kevin
Kinsella, Anthony
Clarke, Mary
Turner, Niall
O'Callaghan, Eadbhard
Affiliation
DETECT Services, Avila House, Block 5 Blackrock Business Park, Blackrock, Co Dublin, Ireland. johnlyne@mail.comIssue Date
2012-03Keywords
BIPOLAR DISORDERDIAGNOSIS
EPIDEMIOLOGY
DEPRESSIVE DISORDER
PSYCHIATRIC STATUS RATING SCALES
PSYCHOTIC DISORDERS
PSYCHOSIS
SCHIZOPHRENIA
IRELAND
PREVALENCE
MeSH
AdolescentAdult
Aged
Bipolar Disorder
Depressive Disorder, Major
Female
Humans
Ireland
Male
Middle Aged
Prevalence
Psychiatric Status Rating Scales
Psychotic Disorders
Retrospective Studies
Schizophrenia
Schizophrenia, Paranoid
Severity of Illness Index
Young Adult
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Prevalence of item level negative symptoms in first episode psychosis diagnoses. 2012, 135 (1-3):128-33 Schizophr. Res.Journal
Schizophrenia researchDOI
10.1016/j.schres.2012.01.004PubMed ID
22281102Abstract
The relevance of negative symptoms across the diagnostic spectrum of the psychoses remains uncertain. The purpose of this study was to report on prevalence of item and subscale level negative symptoms across the first episode psychosis (FEP) diagnostic spectrum in an epidemiological sample, and to ascertain whether items and subscales were more prevalent in a schizophrenia spectrum diagnoses group compared to an 'all other psychotic diagnoses' group. We measured negative symptoms in 330 patients presenting with FEP using the Scale for Assessment of Negative Symptoms (SANS), and ascertained diagnosis using the Structured Clinical Interview for DSM IV. Prevalence of SANS items and subscales were tabulated across all psychotic diagnoses, and logistic regression analysis determined which items and subscales were predictive of schizophrenia spectrum diagnoses. SANS items were most prevalent in schizophrenia spectrum conditions but frequently presented in other FEP diagnoses, particularly substance induced psychotic disorder and Major Depressive Disorder. Brief psychotic disorder and bipolar disorders had low levels of negative symptoms. SANS items and subscales which significantly predicted schizophrenia spectrum diagnoses, were also frequently present in some of the other psychotic diagnoses. Conclusions: SANS items have high prevalence in FEP, and while commonest in schizophrenia spectrum conditions are not restricted to this diagnostic subgroup.Item Type
ArticleLanguage
enISSN
1573-2509ae974a485f413a2113503eed53cd6c53
10.1016/j.schres.2012.01.004
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