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dc.contributor.authorFerguson, W
dc.contributor.authorMayne, P D
dc.contributor.authorLennon, B
dc.contributor.authorButler, K
dc.contributor.authorCafferkey, M
dc.date.accessioned2012-12-20T11:11:57Z
dc.date.available2012-12-20T11:11:57Z
dc.date.issued2008-08-20
dc.identifier.citationSusceptibility of pregnant women to toxoplasma infection--potential benefits for newborn screening., 101 (7):220-1 Ir Med Jen_GB
dc.identifier.issn0332-3102
dc.identifier.pmid18807815
dc.identifier.urihttp://hdl.handle.net/10147/263308
dc.description.abstractCongenital toxoplasmosis (CT) arises as a result of new acquisition of Toxoplasma infection by a susceptible woman during pregnancy. Early detection of CT through neonatal screening programmes could optimize management and improve infant outcome. This study sought to estimate the prevalence of Toxoplasma susceptibility in pregnant women. As detection of Toxoplasma antibodies in neonatal blood reflects maternal exposure history, maternal antibody seroprevalence was determined using anonymized residual blood from newborn screening cards. A total of 20,252 cards were tested in 1 year. 4,991 (24.6%) cards tested positive for Toxoplasma antibody. Results were stratified by county. Toxoplasma antibody seroprevalence rates of 25% indicated that Toxoplasma infection is common in Ireland and that up to 75% of women remain susceptible to primary infection during pregnancy. This study aimed to a) determine the seroprevalence of Toxoplasma antibody in pregnant women, and hence b) estimate the risk for acquisition of primary toxoplasmosis in pregnancy in order to support an application to fund a pilot newborn screening programme.
dc.language.isoenen
dc.rightsArchived with thanks to Irish medical journalen_GB
dc.subject.meshDisease Susceptibility
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant, Newborn
dc.subject.meshIreland
dc.subject.meshNeonatal Screening
dc.subject.meshPregnancy
dc.subject.meshRisk Factors
dc.subject.meshSeroepidemiologic Studies
dc.subject.meshToxoplasmosis, Congenital
dc.titleSusceptibility of pregnant women to toxoplasma infection--potential benefits for newborn screening.en_GB
dc.typeArticleen
dc.contributor.departmentThe Rotunda Hospital, Parnell Street, Dublin. wferguson@rotunda.ieen_GB
dc.identifier.journalIrish medical journalen_GB
dc.description.provinceLeinsteren
refterms.dateFOA2018-08-23T02:57:17Z
html.description.abstractCongenital toxoplasmosis (CT) arises as a result of new acquisition of Toxoplasma infection by a susceptible woman during pregnancy. Early detection of CT through neonatal screening programmes could optimize management and improve infant outcome. This study sought to estimate the prevalence of Toxoplasma susceptibility in pregnant women. As detection of Toxoplasma antibodies in neonatal blood reflects maternal exposure history, maternal antibody seroprevalence was determined using anonymized residual blood from newborn screening cards. A total of 20,252 cards were tested in 1 year. 4,991 (24.6%) cards tested positive for Toxoplasma antibody. Results were stratified by county. Toxoplasma antibody seroprevalence rates of 25% indicated that Toxoplasma infection is common in Ireland and that up to 75% of women remain susceptible to primary infection during pregnancy. This study aimed to a) determine the seroprevalence of Toxoplasma antibody in pregnant women, and hence b) estimate the risk for acquisition of primary toxoplasmosis in pregnancy in order to support an application to fund a pilot newborn screening programme.


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