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    Susceptibility of pregnant women to toxoplasma infection--potential benefits for newborn screening.

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    Authors
    Ferguson, W
    Mayne, P D
    Lennon, B
    Butler, K
    Cafferkey, M
    Affiliation
    The Rotunda Hospital, Parnell Street, Dublin. wferguson@rotunda.ie
    Issue Date
    2008-08-20
    MeSH
    Disease Susceptibility
    Female
    Humans
    Infant, Newborn
    Ireland
    Neonatal Screening
    Pregnancy
    Risk Factors
    Seroepidemiologic Studies
    Toxoplasmosis, Congenital
    
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    Citation
    Susceptibility of pregnant women to toxoplasma infection--potential benefits for newborn screening., 101 (7):220-1 Ir Med J
    Journal
    Irish medical journal
    URI
    http://hdl.handle.net/10147/263308
    PubMed ID
    18807815
    Abstract
    Congenital toxoplasmosis (CT) arises as a result of new acquisition of Toxoplasma infection by a susceptible woman during pregnancy. Early detection of CT through neonatal screening programmes could optimize management and improve infant outcome. This study sought to estimate the prevalence of Toxoplasma susceptibility in pregnant women. As detection of Toxoplasma antibodies in neonatal blood reflects maternal exposure history, maternal antibody seroprevalence was determined using anonymized residual blood from newborn screening cards. A total of 20,252 cards were tested in 1 year. 4,991 (24.6%) cards tested positive for Toxoplasma antibody. Results were stratified by county. Toxoplasma antibody seroprevalence rates of 25% indicated that Toxoplasma infection is common in Ireland and that up to 75% of women remain susceptible to primary infection during pregnancy. This study aimed to a) determine the seroprevalence of Toxoplasma antibody in pregnant women, and hence b) estimate the risk for acquisition of primary toxoplasmosis in pregnancy in order to support an application to fund a pilot newborn screening programme.
    Item Type
    Article
    Language
    en
    ISSN
    0332-3102
    Collections
    Rotunda Hospital

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