Challenges with current inhaled treatments for chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis.
AffiliationNational Children's Hospital, Tallaght, Dublin, Ireland. Peter.Greally@amnch.ie
Drug Resistance, Bacterial
Respiratory Tract Infections
MetadataShow full item record
CitationChallenges with current inhaled treatments for chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis. 2012, 28 (6):1059-67 Curr Med Res Opin
PublisherCurrent medical research and opinion
JournalCurrent medical research and opinion
AbstractPseudomonas aeruginosa (Pa) is the predominant pathogen infecting the airways of patients with cystic fibrosis (CF). Initial colonization is usually transient and associated with non-mucoid strains, which can be eradicated if identified early. This strategy can prevent, or at least delay, chronic Pa infection, which eventually develops in the majority of patients by their late teens or early adulthood. This article discusses the management and latest treatment developments of Pa lung infection in patients with CF, with a focus on nebulized antibiotic therapy.