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dc.contributor.authorO'Reilly, R
dc.contributor.authorFitzpatrick, P
dc.contributor.authorLeen, G
dc.contributor.authorElnazir, B
dc.contributor.authorGreally, P
dc.date.accessioned2012-12-06T15:29:14Z
dc.date.available2012-12-06T15:29:14Z
dc.date.issued2009-02
dc.identifier.citationSevere bone demineralisation is associated with higher mortality in children with cystic fibrosis. 2009, 102 (2):47-9 Ir Med Jen_GB
dc.identifier.issn0332-3102
dc.identifier.pmid19405318
dc.identifier.urihttp://hdl.handle.net/10147/254780
dc.description.abstractDecreased bone mineral density (BMD) is an emerging problem for clinicians who care for children with Cystic fibrosis (CF). The aim of this study was to determine prevalence and assess risk factors for reduced BMD in our adolescent population with CF. All bone densitometry scans (n=99) performed on children (n=79) with a mean age 13.6 (10-19.2) years over a 7 year period (2000-2007) were reviewed. Patient records were reviewed for correlating clinical data. Low BMD is frequently present in adults and children with variable reports (36-66%). In our study, BMD expressed as z score of L2-L4 spine was reduced in a total of 50% children with a preponderance of males. Bone demineralization was strongly associated with increasing age (p=0.03), diminished lung function (p=0.027), reduced body mass index (p=0.001) and treatment with oral corticosteroids (p=0.02).
dc.language.isoenen
dc.publisherIrish medical journalen_GB
dc.rightsArchived with thanks to Irish medical journalen_GB
dc.subject.meshAbsorptiometry, Photon
dc.subject.meshAdolescent
dc.subject.meshAdrenal Cortex Hormones
dc.subject.meshAdult
dc.subject.meshAge Factors
dc.subject.meshBody Mass Index
dc.subject.meshBone Demineralization, Pathologic
dc.subject.meshBone Density
dc.subject.meshChild
dc.subject.meshCystic Fibrosis
dc.subject.meshFemale
dc.subject.meshForced Expiratory Volume
dc.subject.meshHumans
dc.subject.meshIreland
dc.subject.meshMale
dc.subject.meshMutation
dc.subject.meshPrevalence
dc.subject.meshRisk Factors
dc.subject.meshYoung Adult
dc.titleSevere bone demineralisation is associated with higher mortality in children with cystic fibrosis.en_GB
dc.typeArticleen
dc.contributor.departmentCystic Fibrosis Department, National Children's Hospital, Tallaght, Dublin. ruthieor@hotmail.comen_GB
dc.identifier.journalIrish medical journalen_GB
dc.description.provinceLeinsteren
html.description.abstractDecreased bone mineral density (BMD) is an emerging problem for clinicians who care for children with Cystic fibrosis (CF). The aim of this study was to determine prevalence and assess risk factors for reduced BMD in our adolescent population with CF. All bone densitometry scans (n=99) performed on children (n=79) with a mean age 13.6 (10-19.2) years over a 7 year period (2000-2007) were reviewed. Patient records were reviewed for correlating clinical data. Low BMD is frequently present in adults and children with variable reports (36-66%). In our study, BMD expressed as z score of L2-L4 spine was reduced in a total of 50% children with a preponderance of males. Bone demineralization was strongly associated with increasing age (p=0.03), diminished lung function (p=0.027), reduced body mass index (p=0.001) and treatment with oral corticosteroids (p=0.02).


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