Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.
Warren, Richard B
Ryan, Anthony W
Morgan, Ann W
Griffiths, Christopher E M
Bruce, Ian N
AffiliationArthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Age of Onset
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
MetadataShow full item record
CitationEvidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris. 2011, 70 (6):1016-9 Ann. Rheum. Dis.
PublisherAnnals of the rheumatic diseases
JournalAnnals of the rheumatic diseases
AbstractThere is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to the identification of distinct underlying aetiological pathways. Recent studies identified single nucleotide polymorphisms (SNPs) in the interleukin 13 (IL-13) gene region as risk factors for PsV. Further investigations in one of these studies found the effect to be primarily restricted to PsA, thus suggesting the discovery of a specific genetic risk factor for PsA. Given this intriguing evidence, association to this gene was investigated in large collections of PsA and PsV patients and healthy controls.