• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • Tallaght University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • Tallaght University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5079
    UlsterS
    5079
    Connacht
    1698
    Munster
    58
    Leinster
    465

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Successful Use of Alternative Anticoagulants in the Management of Heparin-induced Thrombocytopenia with Thrombotic Complications: Report of 5 cases and review of literature.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Alkindi, Salam
    Smith, Owen P
    Enright, Helen
    Affiliation
    Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman;
    Issue Date
    2011-08
    
    Metadata
    Show full item record
    Citation
    Successful Use of Alternative Anticoagulants in the Management of Heparin-induced Thrombocytopenia with Thrombotic Complications: Report of 5 cases and review of literature. 2011, 11 (3):391-8 Sultan Qaboos Univ Med J
    Publisher
    Sultan Qaboos University medical journal
    Journal
    Sultan Qaboos University medical journal
    URI
    http://hdl.handle.net/10147/254753
    PubMed ID
    22087382
    Abstract
    Heparin is one of the most frequently used anticoagulants. It is easy to use, but can be associated with life-threatening side effects. One of these is heparin-induced thrombocytopenia syndrome (HITS), which develops in about 3-5% of patients exposed to heparin and is associated with thrombosis in 1% of cases. We report here the successful treatment of five patients with HITS who were treated with alternative anticoagulants namely danaparoid or hirudin. The median time between their exposure to heparin and onset of symptoms and or signs was 10.2 days (range 7-14 days). Platelet counts decreased to a mean of 38.4 x 10(9) /l (12-82 x 10(9)/l). All five patients had evidence of thrombosis; four patients had clinical and radiological evidence of pulmonary emboli, one patient had confirmed deep vein thrombosis (DVT) and one patient had extensive skin necrosis of the thighs and abdomen. Platelet aggregation test were positive in two patients, inconclusive in one patient and negative in two patients. Two patients were anticoagulated with danaparoid and three with hirudin until their platelet counts returned to normal between 4 and 14 days (average 6 days) following the recognition of the syndrome. Our patients had significant morbidity, but no mortality. Immediate withdrawal of heparin is of paramount importance and introduction of alternative anticoagulant is necessary in the presence of thrombosis.
    Item Type
    Article
    Language
    en
    ISSN
    2075-0528
    Collections
    Tallaght University Hospital

    entitlement

    Related articles

    • The management of heparin-induced thrombocytopenia.
    • Authors: Keeling D, Davidson S, Watson H, Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology
    • Issue date: 2006 May
    • Heparin-induced thrombocytopenia and thrombosis syndrome: in vivo cross-reactivity with danaparoid and successful treatment with r-Hirudin.
    • Authors: Keng TB, Chong BH
    • Issue date: 2001 Aug
    • Anticoagulative management of patients requiring left ventricular assist device implantation and suffering from heparin-induced thrombocytopenia type II.
    • Authors: Christiansen S, Jahn UR, Meyer J, Scheld HH, Van Aken H, Kehrel BE, Hammel D
    • Issue date: 2000 Mar
    • Anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II and renal impairment using heparin and the platelet glycoprotein IIb-IIIa antagonist tirofiban.
    • Authors: Koster A, Kukucka M, Bach F, Meyer O, Fischer T, Mertzlufft F, Loebe M, Hetzer R, Kuppe H
    • Issue date: 2001 Feb
    • [Heparin induced thrombocytopenia: case report with acute thrombotic complications and literature review].
    • Authors: Plassat R, Cognet F, Ternisien C, Ménoret N, Dubus-Bausière V, Brunel P, Bontoux L, Bernat C, Richard I
    • Issue date: 2002 May
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.