Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis.
Authors
Bowes, JohnFlynn, Edward
Ho, Pauline
Aly, Batool
Morgan, Ann W
Marzo-Ortega, Helena
Coates, Laura
McManus, Ross
Ryan, Anthony W
Kane, David
Korendowych, Eleanor
McHugh, Neil
FitzGerald, Oliver
Packham, Jonathan
Bruce, Ian N
Barton, Anne
Affiliation
Arthritis Research UK Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK.Issue Date
2010-12MeSH
Arthritis, PsoriaticCase-Control Studies
Chromosomes, Human, Pair 1
Cornified Envelope Proline-Rich Proteins
Gene Deletion
Genetic Predisposition to Disease
Genotype
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Metadata
Show full item recordCitation
Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis. 2010, 69 (12):2199-203 Ann. Rheum. Dis.Publisher
Annals of the rheumatic diseasesJournal
Annals of the rheumatic diseasesDOI
10.1136/ard.2010.130575PubMed ID
20643763Abstract
A common deletion mapping to the psoriasis susceptibility locus 4 on chromosome 1q21, encompassing two genes of the late cornified envelope (LCE) gene cluster, has been associated with an increased risk of psoriasis vulgaris (PsV). One previous report found no association of the deletion with psoriatic arthritis (PsA), suggesting it may be a specific risk factor for PsV. Given the genetic overlap between PsA and PsV, a study was undertaken to investigate whether single nucleotide polymorphisms (SNPs) mapping to this locus are risk factors for PsA in a UK and Irish population.Item Type
ArticleLanguage
enISSN
1468-2060ae974a485f413a2113503eed53cd6c53
10.1136/ard.2010.130575