Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis.
Morgan, Ann W
Ryan, Anthony W
Bruce, Ian N
AffiliationArthritis Research UK Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK.
Chromosomes, Human, Pair 1
Cornified Envelope Proline-Rich Proteins
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
MetadataShow full item record
CitationVariants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis. 2010, 69 (12):2199-203 Ann. Rheum. Dis.
PublisherAnnals of the rheumatic diseases
JournalAnnals of the rheumatic diseases
AbstractA common deletion mapping to the psoriasis susceptibility locus 4 on chromosome 1q21, encompassing two genes of the late cornified envelope (LCE) gene cluster, has been associated with an increased risk of psoriasis vulgaris (PsV). One previous report found no association of the deletion with psoriatic arthritis (PsA), suggesting it may be a specific risk factor for PsV. Given the genetic overlap between PsA and PsV, a study was undertaken to investigate whether single nucleotide polymorphisms (SNPs) mapping to this locus are risk factors for PsA in a UK and Irish population.