Platelet degranulation and monocyte-platelet complex formation are increased in the acute and convalescent phases after ischaemic stroke or transient ischaemic attack.
Authors
McCabe, Dominick J HHarrison, Paul
Mackie, Ian J
Sidhu, Paul S
Purdy, Gordon
Lawrie, Andrew S
Watt, Hilary
Brown, Martin M
Machin, Samuel J
Affiliation
Stroke Research Unit, Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London, London, UK. d.mccabe@ion.ucl.ac.ukIssue Date
2004-06MeSH
Acute DiseaseAged
Antigens, CD45
Biological Markers
Blood Platelets
Case-Control Studies
Cell Adhesion
Female
Flow Cytometry
Humans
Ischemic Attack, Transient
Leukocytes
Male
Phycoerythrin
Platelet Activation
Platelet Adhesiveness
Statistics, Nonparametric
Stroke
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Platelet degranulation and monocyte-platelet complex formation are increased in the acute and convalescent phases after ischaemic stroke or transient ischaemic attack. 2004, 125 (6):777-87 Br. J. Haematol.Publisher
British journal of haematologyJournal
British journal of haematologyDOI
10.1111/j.1365-2141.2004.04983.xPubMed ID
15180868Abstract
Flow cytometric studies suggest that platelets are activated in ischaemic stroke or transient ischaemic attack (TIA). However, few studies have measured circulating leucocyte-platelet complexes in this patient population. Whole blood flow cytometry was used to quantify the expression of CD62P-, CD63-, and PAC1-binding, and the percentages of leucocyte-platelet complexes in acute (1-27 d, n = 79) and convalescent (79-725 d, n = 70) ischaemic cerebrovascular disease (CVD) patients compared with controls without CVD (n = 27). We performed a full blood count, and measured plasma levels of soluble P-selectin, soluble E-selectin, and von Willebrand factor antigen (VWF:Ag) as additional markers of platelet and/or endothelial cell activation. The median percentage CD62P expression and the median percentage monocyte-platelet complexes were higher in both acute and convalescent CVD patients than controls (PItem Type
ArticleLanguage
enISSN
0007-1048ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2141.2004.04983.x
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