Affiliation
Department of Dermatology, The Adelaide and Meath Hospital Incorporating the National Children's Hospital, Dublin, Ireland. sineadfield@hotmail.comIssue Date
2008-03MeSH
FemaleHumans
Hypoglycemia
Insulinoma
Middle Aged
Pancreatectomy
Pancreatic Hormones
Psoriasis
Treatment Outcome
Metadata
Show full item recordCitation
Severe deterioration of psoriasis due to an insulinoma. 2008, 33 (2):145-7 Clin. Exp. Dermatol.Publisher
Clinical and experimental dermatologyJournal
Clinical and experimental dermatologyDOI
10.1111/j.1365-2230.2007.02578.xPubMed ID
18076690Abstract
We report a case of a 56-year-old woman who presented with a severe exacerbation of psoriasis with concurrent hypoglycaemic episodes. Methotrexate 17.5 mg weekly was required to control her psoriasis. Investigation of her hypoglycaemia showed raised levels of insulin, C-peptide and proinsulin. Radiological investigation showed a tumour at the tail of the pancreas and the diagnosis was insulinoma. A spleen-preserving distal pancreatectomy was performed and the hypoglycaemic symptoms resolved. Immediately following the pancreatectomy, methotrexate was stopped and the patient's psoriasis went into remission. During a 2-year follow-up, she has required only minimal topical treatment for her skin.Item Type
ArticleLanguage
enISSN
0307-6938ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2230.2007.02578.x