Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women.
Meinhardt, Udo J
Baxter, Robert C
Ho, Ken K Y
AffiliationPituitary Research Unit, Garvan Institute of Medical Research and Department of Endocrinology, St. Vincent's Hospital, and The University of New South Wales, Sydney, New South Wales 2010, Australia.
Hormone Replacement Therapy
Human Growth Hormone
Selective Estrogen Receptor Modulators
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CitationDifferential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women. 2012, 97 (3):1005-12 J. Clin. Endocrinol. Metab.
JournalThe Journal of clinical endocrinology and metabolism
AbstractGH deficiency causes reduction in muscle and bone mass and an increase in fat mass (FM), the changes reversed by GH replacement. The beneficial effects of GH on fat oxidation and protein anabolism are attenuated more markedly by raloxifene, a selective estrogen receptor modulator, compared with 17β-estradiol. Whether this translates to a long-term detrimental effect on body composition is unknown.
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- Issue date: 2010 May
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