Genetically distinct subsets within ANCA-associated vasculitis.

Authors
Lyons, Paul A
Rayner, Tim F
Trivedi, Sapna
Holle, Julia U
Watts, Richard A
Jayne, David R W
Baslund, Bo
Brenchley, Paul
Bruchfeld, Annette
Chaudhry, Afzal N
Affiliation
Cambridge Institute for Medical Research, and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom. kgcs2@cam.ac.uk
Issue Date
2012-07-19
MeSH
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Case-Control Studies
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotyping Techniques
HLA-DP Antigens
Humans
Major Histocompatibility Complex
Male

Metadata
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Citation
Genetically distinct subsets within ANCA-associated vasculitis. 2012, 367 (3):214-23 N. Engl. J. Med.
Publisher
The New England journal of medicine
Journal
The New England journal of medicine
URI
http://hdl.handle.net/10147/253772
DOI
10.1056/NEJMoa1108735
PubMed ID
22808956
Abstract
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.
Item Type
Article In Press
Language
en
ISSN
1533-4406
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