Prospective study of antibiotic prophylaxis for prostate biopsy involving >1100 men.
AuthorsManecksha, Rustom P
Nason, Gregory J
Cullen, Ivor M
Fennell, Jérôme P
Flynn, Robert J
Thornhill, John A
AffiliationDepartment of Urology, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland. email@example.com
MetadataShow full item record
CitationProspective study of antibiotic prophylaxis for prostate biopsy involving >1100 men. 2012, 2012:650858 ScientificWorldJournal
AbstractWe aimed to compare infection rates for two 3-day antibiotic prophylaxis regimens for transrectal ultrasound-guided prostate biopsy (TRUSgbp) and demonstrate local microbiological trends. In 2008, 558 men and, in 2009, 625 men had TRUSgpb. Regimen 1 (2008) comprised 400 mg Ofloxacin immediately before biopsy and 200 mg 12-hourly for 3 days. Regimen 2 (2009) comprised Ofloxacin 200 mg 12-hourly for 3 days commencing 24 hours before biopsy. 20/558 (3.6%) men had febrile episodes with regimen 1 and 10/625 (1.6%) men with regimen 2 (P = 0.03). E. coli was the most frequently isolated organism. Overall, 7/13 (54%) of positive urine cultures were quinolone resistant and (5/13) 40% were multidrug resistant. Overall, 5/9 (56%) patients with septicaemia were quinolone resistant. All patients were sensitive to Meropenem. There was 1 (0.2%) death with regimen 1. Commencing Ofloxacin 24 hours before TRUSgpb reduced the incidence of febrile episodes significantly. We observed the emergence of quinolone and multidrug-resistant E. coli. Meropenem should be considered for unresolving sepsis.
- Fluoroquinolone-resistant E. coli in intestinal flora of patients undergoing transrectal ultrasound-guided prostate biopsy--should we reassess our practices for antibiotic prophylaxis?
- Authors: Steensels D, Slabbaert K, De Wever L, Vermeersch P, Van Poppel H, Verhaegen J
- Issue date: 2012 Jun
- Prevalence of fluoroquinolone-resistant Escherichia coli before and incidence of acute bacterial prostatitis after prostate biopsy.
- Authors: Minamida S, Satoh T, Tabata K, Kimura M, Tsumura H, Kurosaka S, Matsumoto K, Fujita T, Iwamura M, Baba S
- Issue date: 2011 Dec
- Febrile reactions after transrectal ultrasound-guided prostatic biopsy: a retrospective study.
- Authors: Hedelin H, Claesson BE, Wilpart A
- Issue date: 2011 Dec
- Clinical importance of the antibiotic regimen in transrectal ultrasound-guided biopsy: quinolone versus cephalosporin.
- Authors: Lee JK, Lee S, Hong SK, Byun SS, Lee SE
- Issue date: 2016 Aug 24
- Cost-effectiveness of standard vs intensive antibiotic regimens for transrectal ultrasonography (TRUS)-guided prostate biopsy prophylaxis.
- Authors: Adibi M, Pearle MS, Lotan Y
- Issue date: 2012 Jul