Increased spontaneous apoptosis, but not survivin expression, is associated with histomorphologic response to neoadjuvant chemoradiation in rectal cancer.
Authors
McDowell, Dermot TSmith, Fraser M
Reynolds, John V
Maher, Stephen G
Adida, Collette
Crotty, Paul
Gaffney, Eoin F
Hollywood, Donal
Mehigan, Brian
Stephens, Richard B
Kennedy, M J
Affiliation
Department of Academic Surgery, St James's Hospital, Dublin, Ireland.Issue Date
2009-11MeSH
ApoptosisBiopsy
Cell Proliferation
Chemotherapy, Adjuvant
Gene Expression Regulation, Neoplastic
Humans
Inhibitor of Apoptosis Proteins
Ki-67 Antigen
Lymph Nodes
Microtubule-Associated Proteins
Neoadjuvant Therapy
Neoplasm Staging
Radiotherapy, Adjuvant
Rectal Neoplasms
Staining and Labeling
Metadata
Show full item recordCitation
Increased spontaneous apoptosis, but not survivin expression, is associated with histomorphologic response to neoadjuvant chemoradiation in rectal cancer. 2009, 24 (11):1261-9 Int J Colorectal DisJournal
International journal of colorectal diseaseDOI
10.1007/s00384-009-0755-6PubMed ID
19593573Abstract
Survivin has been shown to be an important mediator of cellular radioresistance in vitro. This study aims to compare survivin expression and apoptosis to histomorphologic responses to neoadjuvant radiochemotherapy (RCT) in rectal cancer.Item Type
ArticleLanguage
enISSN
1432-1262ae974a485f413a2113503eed53cd6c53
10.1007/s00384-009-0755-6
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