Increased spontaneous apoptosis, but not survivin expression, is associated with histomorphologic response to neoadjuvant chemoradiation in rectal cancer.
AuthorsMcDowell, Dermot T
Smith, Fraser M
Reynolds, John V
Maher, Stephen G
Gaffney, Eoin F
Stephens, Richard B
Kennedy, M J
AffiliationDepartment of Academic Surgery, St James's Hospital, Dublin, Ireland.
Gene Expression Regulation, Neoplastic
Inhibitor of Apoptosis Proteins
Staining and Labeling
MetadataShow full item record
CitationIncreased spontaneous apoptosis, but not survivin expression, is associated with histomorphologic response to neoadjuvant chemoradiation in rectal cancer. 2009, 24 (11):1261-9 Int J Colorectal Dis
JournalInternational journal of colorectal disease
AbstractSurvivin has been shown to be an important mediator of cellular radioresistance in vitro. This study aims to compare survivin expression and apoptosis to histomorphologic responses to neoadjuvant radiochemotherapy (RCT) in rectal cancer.