AffiliationProfessorial Surgical Unit, University of Dublin, Trinity College, The Trinity Centre for Health Sciences, Adelaide & Meath Hospital Inc. NCH, Tallaght, Dublin, Ireland.
MeSHAnti-Inflammatory Agents, Non-Steroidal
Vascular Endothelial Growth Factor A
MetadataShow full item record
CitationCOX-2, VEGF and tumour angiogenesis. 2009, 7 (3):174-80 Surgeon
JournalThe surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
AbstractEpidemiological evidence suggests a protective effective of regular NSAID use against developing cancer. Cyclooxygenase-2, a target of NSAIDs, is upregulated in many cancers and has been associated with increased VEGF production and angiogenesis. Angiogenesis is the formation of new vessels from existing vasculature and as an essential process for tumour development represents an important therapeutic target. Following an extensive review of the literature this article details the current knowledge on the role of COX-2 in tumorigenesis focusing on its relationship to angiogenesis and VEGF production by tumour cells. While COX-2 is clearly detrimental to prognosis and NSAIDs have a beneficial effect, the possibility of COX-2 independent effects being partly or wholly responsible for this benefit cannot be excluded.
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