Vascular endothelial growth factor and not cyclooxygenase 2 promotes endothelial cell viability in the pancreatic tumor microenvironment.
Authors
Toomey, Desmond PManahan, Ellen
McKeown, Ciara
Rogers, Annamarie
McMillan, Helen
Geary, Michael
Conlon, Kevin C
Murphy, Joseph F
Affiliation
Professorial Surgical Unit, University of Dublin, Trinity College, Dublin, Ireland.Issue Date
2010-07MeSH
Angiogenesis InhibitorsAnti-Inflammatory Agents, Non-Steroidal
Cell Survival
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Dinoprostone
Endothelium, Vascular
Humans
Neovascularization, Pathologic
Pancreatic Neoplasms
Pyrazoles
Sulfonamides
Tumor Cells, Cultured
Vascular Endothelial Growth Factors
Metadata
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Vascular endothelial growth factor and not cyclooxygenase 2 promotes endothelial cell viability in the pancreatic tumor microenvironment. 2010, 39 (5):595-603 PancreasPublisher
PancreasJournal
PancreasDOI
10.1097/MPA.0b013e3181c6575dPubMed ID
20118820Abstract
Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in angiogenesis and VEGF regulation.Item Type
ArticleLanguage
enISSN
1536-4828ae974a485f413a2113503eed53cd6c53
10.1097/MPA.0b013e3181c6575d
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