• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • St. Patrick's University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • St. Patrick's University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5081
    UlsterS
    5081
    Connacht
    1698
    Munster
    58
    Leinster
    466

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Promoter characterization and genomic organization of the human X11β gene APBA2.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Hao, Yan
    Chai, Ka-Ho
    McLoughlin, Declan M
    Chan, Ho Yin Edwin
    Lau, Kwok-Fai
    Affiliation
    Biochemistry Program, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR.
    Issue Date
    2012-02-15
    MeSH
    Base Sequence
    Binding Sites
    Brain
    Cadherins
    Carrier Proteins
    DNA Methylation
    Gene Expression Regulation
    Genome, Human
    Humans
    Molecular Sequence Data
    Mutagenesis
    Nerve Tissue Proteins
    Promoter Regions, Genetic
    Transcription, Genetic
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Promoter characterization and genomic organization of the human X11β gene APBA2. 2012, 23 (3):146-51 Neuroreport
    Journal
    Neuroreport
    URI
    http://hdl.handle.net/10147/244195
    DOI
    10.1097/WNR.0b013e32834f1934
    PubMed ID
    22222501
    Abstract
    Overexpression of neuronal adaptor protein X11β has been shown to decrease the production of amyloid-β, a toxic peptide deposited in Alzheimer's disease brains. Therefore, manipulation of the X11β level may represent a potential therapeutic strategy for Alzheimer's disease. As X11β expression can be regulated at the transcription level, we determined the genomic organization and the promoter of the human X11β gene, amyloid β A4 precursor protein-binding family A member 2 (APBA2). By RNA ligase-mediated rapid amplification of cDNA ends, a single APBA2 transcription start site and the complete sequence of exon 1 were identified. The APBA2 promoter was located upstream of exon 1 and was more active in neurons. The core promoter contains several CpG dinucleotides, and was strongly suppressed by DNA methylation. In addition, mutagenesis analysis revealed a putative Pax5-binding site within the promoter. Together, APBA2 contains a potent neuronal promoter whose activity may be regulated by DNA methylation and Pax5.
    Item Type
    Article
    Language
    en
    ISSN
    1473-558X
    ae974a485f413a2113503eed53cd6c53
    10.1097/WNR.0b013e32834f1934
    Scopus Count
    Collections
    St. Patrick's University Hospital

    entitlement

    Related articles

    • Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1.
    • Authors: Zhou D, Masri S, Ye JJ, Chen S
    • Issue date: 2005 Nov 21
    • The promoter of Alzheimer's disease amyloid A4 precursor gene.
    • Authors: Salbaum JM, Weidemann A, Masters CL, Beyreuther K
    • Issue date: 1989
    • Copy number and sequence variants implicate APBA2 as an autism candidate gene.
    • Authors: Babatz TD, Kumar RA, Sudi J, Dobyns WB, Christian SL
    • Issue date: 2009 Dec
    • Characterization of the human PRIP-1 gene structure and transcriptional regulation.
    • Authors: Murakami A, Matsuda M, Nakasima A, Hirata M
    • Issue date: 2006 Nov 1
    • The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.
    • Authors: Lee JH, Lau KF, Perkinton MS, Standen CL, Rogelj B, Falinska A, McLoughlin DM, Miller CC
    • Issue date: 2004 Nov 19
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.