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    Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer.

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    Authors
    Kevans, David
    Gorman, Sheeona
    Tosetto, Miriam
    Sheahan, Kieran
    O'Donoghue, Diarmuid
    Mulcahy, Hugh
    O'Sullivan, Jacintha
    Affiliation
    Centre for Colorectal Disease, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
    Issue Date
    2012-06
    MeSH
    Antineoplastic Agents
    Apoptosis
    Blotting, Western
    Cell Hypoxia
    Cell Line, Tumor
    Cell Proliferation
    Clusterin
    Colorectal Neoplasms
    Drug Resistance, Neoplasm
    Enzyme-Linked Immunosorbent Assay
    Flow Cytometry
    Humans
    Transfection
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    Citation
    Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer. 2012, 43 (2):305-13 J Gastrointest Cancer
    Journal
    Journal of gastrointestinal cancer
    URI
    http://hdl.handle.net/10147/244020
    DOI
    10.1007/s12029-011-9277-x
    PubMed ID
    21487682
    Abstract
    In vitro studies have shown that clusterin modulates treatment sensitivity in a number of human cancers; however, the interaction between clusterin expression and hypoxia in controlling treatment response in CRC has not previously been examined. The aim of this study was to assess the effect of clusterin overexpression in CRC cells on sensitivity to 5-fluorouracil (5-FU), oxaliplatin and FOLFOX treatment under normoxic and graded hypoxic conditions.
    Item Type
    Article
    Language
    en
    ISSN
    1941-6636
    ae974a485f413a2113503eed53cd6c53
    10.1007/s12029-011-9277-x
    Scopus Count
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    St. Vincent's University Hospital

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