Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer.
Authors
Kevans, DavidGorman, Sheeona
Tosetto, Miriam
Sheahan, Kieran
O'Donoghue, Diarmuid
Mulcahy, Hugh
O'Sullivan, Jacintha
Affiliation
Centre for Colorectal Disease, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.Issue Date
2012-06MeSH
Antineoplastic AgentsApoptosis
Blotting, Western
Cell Hypoxia
Cell Line, Tumor
Cell Proliferation
Clusterin
Colorectal Neoplasms
Drug Resistance, Neoplasm
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Humans
Transfection
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Show full item recordCitation
Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer. 2012, 43 (2):305-13 J Gastrointest CancerJournal
Journal of gastrointestinal cancerDOI
10.1007/s12029-011-9277-xPubMed ID
21487682Abstract
In vitro studies have shown that clusterin modulates treatment sensitivity in a number of human cancers; however, the interaction between clusterin expression and hypoxia in controlling treatment response in CRC has not previously been examined. The aim of this study was to assess the effect of clusterin overexpression in CRC cells on sensitivity to 5-fluorouracil (5-FU), oxaliplatin and FOLFOX treatment under normoxic and graded hypoxic conditions.Item Type
ArticleLanguage
enISSN
1941-6636ae974a485f413a2113503eed53cd6c53
10.1007/s12029-011-9277-x
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