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In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer.

dc.contributor.authorMurphy, Therese M
dc.contributor.authorSullivan, Linda
dc.contributor.authorLane, Caroline
dc.contributor.authorO'Connor, Lisa
dc.contributor.authorBarrett, Ciara
dc.contributor.authorHollywood, Donal
dc.contributor.authorLynch, Thomas
dc.contributor.authorLawler, Mark
dc.contributor.authorPerry, Antoinette S
dc.date.accessioned2012-09-12T15:02:54Z
dc.date.available2012-09-12T15:02:54Z
dc.date.issued2011-01-01
dc.identifier.citationIn silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer. 2011, 71 (1):1-17 Prostateen_GB
dc.identifier.issn1097-0045
dc.identifier.pmid20564325
dc.identifier.doi10.1002/pros.21212
dc.identifier.urihttp://hdl.handle.net/10147/243634
dc.description.abstractAberrant DNA methylation has been implicated as a key survival mechanism in cancer, whereby promoter hypermethylation silences genes essential for many cellular processes including apoptosis. Limited data is available on the methylation profile of apoptotic genes in prostate cancer (CaP). The aim of this study was to profile methylation of apoptotic-related genes in CaP using denaturing high performance liquid chromatography (DHPLC).
dc.language.isoenen
dc.publisherWileyen_GB
dc.rightsArchived with thanks to The Prostateen_GB
dc.subjectApoptosis/geneticsen_GB
dc.subjectDNA Methylationen_GB
dc.subjectGene Targetingen_GB
dc.subjectProstatic Neoplasms/geneticsen_GB
dc.subject.meshAdenovirus Infections, Human
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshApoptosis
dc.subject.meshCell Line, Tumor
dc.subject.meshChromatography, High Pressure Liquid
dc.subject.meshCohort Studies
dc.subject.meshDNA Methylation
dc.subject.meshGene Expression Regulation, Neoplastic
dc.subject.meshGene Targeting
dc.subject.meshGenetic Loci
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Staging
dc.subject.meshNucleic Acid Denaturation
dc.subject.meshPromoter Regions, Genetic
dc.subject.meshProstatic Hyperplasia
dc.subject.meshProstatic Intraepithelial Neoplasia
dc.subject.meshProstatic Neoplasms
dc.titleIn silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer.en_GB
dc.typeOtheren
dc.contributor.departmentProstate Molecular Oncology, Institute of Molecular Medicine, Trinity College, Dublin, Ireland. murphyth@tcd.ieen_GB
dc.identifier.journalThe Prostateen_GB
dc.description.provinceLeinsteren
html.description.abstractAberrant DNA methylation has been implicated as a key survival mechanism in cancer, whereby promoter hypermethylation silences genes essential for many cellular processes including apoptosis. Limited data is available on the methylation profile of apoptotic genes in prostate cancer (CaP). The aim of this study was to profile methylation of apoptotic-related genes in CaP using denaturing high performance liquid chromatography (DHPLC).


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