In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer.
AuthorsMurphy, Therese M
Perry, Antoinette S
AffiliationProstate Molecular Oncology, Institute of Molecular Medicine, Trinity College, Dublin, Ireland. firstname.lastname@example.org
MeSHAdenovirus Infections, Human
Aged, 80 and over
Cell Line, Tumor
Chromatography, High Pressure Liquid
Gene Expression Regulation, Neoplastic
Nucleic Acid Denaturation
Promoter Regions, Genetic
Prostatic Intraepithelial Neoplasia
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CitationIn silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer. 2011, 71 (1):1-17 Prostate
AbstractAberrant DNA methylation has been implicated as a key survival mechanism in cancer, whereby promoter hypermethylation silences genes essential for many cellular processes including apoptosis. Limited data is available on the methylation profile of apoptotic genes in prostate cancer (CaP). The aim of this study was to profile methylation of apoptotic-related genes in CaP using denaturing high performance liquid chromatography (DHPLC).