Solitary fibrous tumor of the central nervous system: a 15-year literature survey of 220 cases (August 1996-July 2011).
Authors
Bisceglia, MicheleGalliani, Carlos
Giannatempo, Giuseppe
Lauriola, Walter
Bianco, Mario
D'angelo, Vincenzo
Pizzolitto, Stefano
Vita, Giulia
Pasquinelli, Gianandrea
Magro, Gaetano
Dor, David Ben
Affiliation
Departments of Pathology, IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo (FG), Italy. bismi@libero.itIssue Date
2011-09MeSH
Brain NeoplasmsCell Proliferation
Female
Humans
Male
Neoplasm Recurrence, Local
Radiotherapy, Adjuvant
Solitary Fibrous Tumors
Spinal Cord Neoplasms
Tumor Markers, Biological
Metadata
Show full item recordCitation
Solitary fibrous tumor of the central nervous system: a 15-year literature survey of 220 cases (August 1996-July 2011). 2011, 18 (5):356-92 Adv Anat PatholJournal
Advances in anatomic pathologyDOI
10.1097/PAP.0b013e318229c004PubMed ID
21841406Abstract
We reviewed the world literature on solitary fibrous tumors of the central nervous system from August 1996 to July 2011, focusing on both clinicopathological features and diagnostic findings. The anatomical distribution of the 220 cases reported so far reveals that most are intracranial and just over one-fifth are intraspinal. In decreasing frequency, intracranial tumors involve the supratentorial and infratentorial compartments, the pontocerebellar angle, the sellar and parasellar regions, and the cranial nerves. Intraspinal tumors are mainly located in the thoracic and cervical segments. Although most solitary fibrous tumors of the central nervous system are dural based, a small subset presents as subpial, intraparenchymal, intraventricular, or as tumors involving the nerve rootlets with no dural connection. Preoperative imaging and intraoperative findings suggest meningioma, schwannoma or neurofibroma, hemangiopericytoma, or pituitary tumors. Immunohistochemistry is critical to establish a definitive histopathological diagnosis. Vimentin, CD34, BCL2, and CD99 are the most consistently positive markers. The usual histologic type generally behaves in a benign manner if complete removal is achieved. Recurrence is anticipated when resection is subtotal or when the tumor exhibits atypical histology. The proliferative index as assessed by MIB1 labeling is of prognostic significance. Occasionally, tumors featuring conventional morphology may recur, perhaps because of minimal residual disease left behind during surgical extirpation. Rare extracranial metastases and tumor-related deaths are on record. Surgery is the treatment of choice. Stereotactic and external beam radiation therapy may be indicated for postsurgical tumor remnants and for unresectable recurrences. Long-term active surveillance of the patients is mandatory.Item Type
Article In PressLanguage
enISSN
1533-4031ae974a485f413a2113503eed53cd6c53
10.1097/PAP.0b013e318229c004