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    Solitary fibrous tumor of the central nervous system: a 15-year literature survey of 220 cases (August 1996-July 2011).

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    Authors
    Bisceglia, Michele
    Galliani, Carlos
    Giannatempo, Giuseppe
    Lauriola, Walter
    Bianco, Mario
    D'angelo, Vincenzo
    Pizzolitto, Stefano
    Vita, Giulia
    Pasquinelli, Gianandrea
    Magro, Gaetano
    Dor, David Ben
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    Affiliation
    Departments of Pathology, IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo (FG), Italy. bismi@libero.it
    Issue Date
    2011-09
    MeSH
    Brain Neoplasms
    Cell Proliferation
    Female
    Humans
    Male
    Neoplasm Recurrence, Local
    Radiotherapy, Adjuvant
    Solitary Fibrous Tumors
    Spinal Cord Neoplasms
    Tumor Markers, Biological
    
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    Citation
    Solitary fibrous tumor of the central nervous system: a 15-year literature survey of 220 cases (August 1996-July 2011). 2011, 18 (5):356-92 Adv Anat Pathol
    Journal
    Advances in anatomic pathology
    URI
    http://hdl.handle.net/10147/241761
    DOI
    10.1097/PAP.0b013e318229c004
    PubMed ID
    21841406
    Abstract
    We reviewed the world literature on solitary fibrous tumors of the central nervous system from August 1996 to July 2011, focusing on both clinicopathological features and diagnostic findings. The anatomical distribution of the 220 cases reported so far reveals that most are intracranial and just over one-fifth are intraspinal. In decreasing frequency, intracranial tumors involve the supratentorial and infratentorial compartments, the pontocerebellar angle, the sellar and parasellar regions, and the cranial nerves. Intraspinal tumors are mainly located in the thoracic and cervical segments. Although most solitary fibrous tumors of the central nervous system are dural based, a small subset presents as subpial, intraparenchymal, intraventricular, or as tumors involving the nerve rootlets with no dural connection. Preoperative imaging and intraoperative findings suggest meningioma, schwannoma or neurofibroma, hemangiopericytoma, or pituitary tumors. Immunohistochemistry is critical to establish a definitive histopathological diagnosis. Vimentin, CD34, BCL2, and CD99 are the most consistently positive markers. The usual histologic type generally behaves in a benign manner if complete removal is achieved. Recurrence is anticipated when resection is subtotal or when the tumor exhibits atypical histology. The proliferative index as assessed by MIB1 labeling is of prognostic significance. Occasionally, tumors featuring conventional morphology may recur, perhaps because of minimal residual disease left behind during surgical extirpation. Rare extracranial metastases and tumor-related deaths are on record. Surgery is the treatment of choice. Stereotactic and external beam radiation therapy may be indicated for postsurgical tumor remnants and for unresectable recurrences. Long-term active surveillance of the patients is mandatory.
    Item Type
    Article In Press
    Language
    en
    ISSN
    1533-4031
    ae974a485f413a2113503eed53cd6c53
    10.1097/PAP.0b013e318229c004
    Scopus Count
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    Beaumont Hospital

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