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    Tinzaparin is safe and effective in the management of hemodialysis catheter thrombosis.

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    Authors
    Quinlan, Catherine
    Bates, Marie
    Cotter, Melanie
    Riordan, Michael
    Waldron, Mary
    Awan, Atif
    Affiliation
    Department of Nephrology, The Children's University Hospital, Dublin, Ireland. CathyQuinlan@mac.com
    Issue Date
    2012-08-27
    MeSH
    Adolescent
    Catheterization, Central Venous
    Child
    Child, Preschool
    Drug Monitoring
    Fibrinolytic Agents
    Heparin, Low-Molecular-Weight
    Humans
    Infant
    Renal Dialysis
    Thrombosis
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    Citation
    Tinzaparin is safe and effective in the management of hemodialysis catheter thrombosis., 58 (3):288-90 ASAIO J.
    Journal
    ASAIO journal (American Society for Artificial Internal Organs : 1992)
    URI
    http://hdl.handle.net/10147/239991
    DOI
    10.1097/MAT.0b013e31824c38c8
    PubMed ID
    22456106
    Abstract
    Children on hemodialysis are at increased risk of thrombosis, especially when dialyzed via a central venous catheter (CVC); there are limited published data regarding the safety and efficacy of tinzaparin in this group. We conducted a retrospective chart review of all children in the National Pediatric Hemodialysis Centre for Ireland diagnosed with a CVC thrombus and treated with subcutaneous tinzaparin over a 10 year period. Seven children were treated with subcutaneous tinzaparin for 10 CVC thrombi. Tinzaparin was commenced at 175 IU/kg/day and the dose was titrated by measuring anti-factor Xa levels, aiming for levels of 0.3-1.0 IU/ml. Treatment was continued until resolution of the CVC thrombus. Restoration of normal flows during dialysis occurred within 3 days in all patients. There were no episodes of bleeding and all children tolerated the treatment well.
    Item Type
    Article
    Language
    en
    ISSN
    1538-943X
    ae974a485f413a2113503eed53cd6c53
    10.1097/MAT.0b013e31824c38c8
    Scopus Count
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    Children's Health Ireland (CHI) at Temple St (formerly Children's University Hospital, Temple St)

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