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    ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.

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    Authors
    Donohoe, Gary
    Rose, Emma
    Frodl, Thomas
    Morris, Derek
    Spoletini, Ilaria
    Adriano, Fulvia
    Bernardini, Sergio
    Caltagirone, Carlo
    Bossù, Paola
    Gill, Michael
    Corvin, Aiden P
    Spalletta, Gianfranco
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    Affiliation
    Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland. donoghug@tcd.ie
    Issue Date
    2011-02-01
    MeSH
    Adult
    Alleles
    Amygdala
    Brain
    Cognition
    Data Interpretation, Statistical
    Demography
    Female
    Genotype
    Heterozygote
    Hippocampus
    Humans
    Image Processing, Computer-Assisted
    Kruppel-Like Transcription Factors
    Magnetic Resonance Imaging
    Male
    Memory
    Polymorphism, Single Nucleotide
    Prefrontal Cortex
    Risk Assessment
    Schizophrenia
    Schizophrenic Psychology
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    Citation
    ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia. 2011, 54 (3):2132-7 Neuroimage
    Journal
    NeuroImage
    URI
    http://hdl.handle.net/10147/238819
    DOI
    10.1016/j.neuroimage.2010.09.089
    PubMed ID
    20934520
    Abstract
    ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared to patient non-carriers, we investigated whether ZNF804A was also associated with variation in brain volume. In a sample of 70 patients and 38 healthy participants we used voxel based morphometry to compare homozygous (AA) carriers of the ZNF804A risk allele to heterozygous and homozygous (AC/CC) non-carriers for both whole brain volume and specific regions implicated in earlier ZNF804A studies-the dorsolateral pre-frontal cortex, the hippocampus, and the amygdala. For patients, but not for controls, we found that homozygous 'AA' risk carriers had relatively larger gray matter volumes than heterozygous/homozygous non-carriers (AC/CC), particularly for hippocampal volumes. These data are consistent with our earlier behavioral data and suggest that ZNF804A is delineating a schizophrenia subtype characterized by relatively intact brain volume. Establishing if this represents a discrete molecular pathogenesis with consequences for nosology and treatment will be an important next step in understanding ZNF084A's role in illness risk.
    Item Type
    Article
    Language
    en
    ISSN
    1095-9572
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuroimage.2010.09.089
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