ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.
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Authors
Donohoe, GaryRose, Emma
Frodl, Thomas
Morris, Derek
Spoletini, Ilaria
Adriano, Fulvia
Bernardini, Sergio
Caltagirone, Carlo
Bossù, Paola
Gill, Michael
Corvin, Aiden P
Spalletta, Gianfranco
Affiliation
Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland. donoghug@tcd.ieIssue Date
2011-02-01MeSH
AdultAlleles
Amygdala
Brain
Cognition
Data Interpretation, Statistical
Demography
Female
Genotype
Heterozygote
Hippocampus
Humans
Image Processing, Computer-Assisted
Kruppel-Like Transcription Factors
Magnetic Resonance Imaging
Male
Memory
Polymorphism, Single Nucleotide
Prefrontal Cortex
Risk Assessment
Schizophrenia
Schizophrenic Psychology
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ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia. 2011, 54 (3):2132-7 NeuroimageJournal
NeuroImageDOI
10.1016/j.neuroimage.2010.09.089PubMed ID
20934520Abstract
ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared to patient non-carriers, we investigated whether ZNF804A was also associated with variation in brain volume. In a sample of 70 patients and 38 healthy participants we used voxel based morphometry to compare homozygous (AA) carriers of the ZNF804A risk allele to heterozygous and homozygous (AC/CC) non-carriers for both whole brain volume and specific regions implicated in earlier ZNF804A studies-the dorsolateral pre-frontal cortex, the hippocampus, and the amygdala. For patients, but not for controls, we found that homozygous 'AA' risk carriers had relatively larger gray matter volumes than heterozygous/homozygous non-carriers (AC/CC), particularly for hippocampal volumes. These data are consistent with our earlier behavioral data and suggest that ZNF804A is delineating a schizophrenia subtype characterized by relatively intact brain volume. Establishing if this represents a discrete molecular pathogenesis with consequences for nosology and treatment will be an important next step in understanding ZNF084A's role in illness risk.Item Type
ArticleLanguage
enISSN
1095-9572ae974a485f413a2113503eed53cd6c53
10.1016/j.neuroimage.2010.09.089