• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • St. James's Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • St. James's Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5079
    UlsterS
    5079
    Connacht
    1698
    Munster
    58
    Leinster
    465

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Williams, H J
    Norton, N
    Dwyer, S
    Moskvina, V
    Nikolov, I
    Carroll, L
    Georgieva, L
    Williams, N M
    Morris, D W
    Quinn, E M
    Giegling, I
    Ikeda, M
    Wood, J
    Lencz, T
    Hultman, C
    Lichtenstein, P
    Thiselton, D
    Maher, B S
    Malhotra, A K
    Riley, B
    Kendler, K S
    Gill, M
    Sullivan, P
    Sklar, P
    Purcell, S
    Nimgaonkar, V L
    Kirov, G
    Holmans, P
    Corvin, A
    Rujescu, D
    Craddock, N
    Owen, M J
    O'Donovan, M C
    Show allShow less
    Affiliation
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.
    Issue Date
    2011-04
    MeSH
    Adult
    Aged
    Bipolar Disorder
    Chromosome Mapping
    Europe
    Exons
    Female
    Gene Frequency
    Genetic Predisposition to Disease
    Genome-Wide Association Study
    Genotype
    Humans
    Kruppel-Like Transcription Factors
    Linkage Disequilibrium
    Male
    Meta-Analysis as Topic
    Middle Aged
    Odds Ratio
    Polymorphism, Single Nucleotide
    Quantitative Trait Loci
    Schizophrenia
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. 2011, 16 (4):429-41 Mol. Psychiatry
    Journal
    Molecular psychiatry
    URI
    http://hdl.handle.net/10147/238807
    DOI
    10.1038/mp.2010.36
    PubMed ID
    20368704
    Abstract
    A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the phenotype was broadened to include bipolar disorder (P=9.96 × 10(-9)). In this study we provide additional evidence for association through meta-analysis of a larger data set (schizophrenia/schizoaffective disorder N=18 945, schizophrenia plus bipolar disorder N=21 274 and controls N=38 675). We also sought to better localize the association signal using a combination of de novo polymorphism discovery in exons, pooled de novo polymorphism discovery spanning the genomic sequence of the locus and high-density linkage disequilibrium (LD) mapping. The meta-analysis provided evidence for association between rs1344706 that surpasses widely accepted benchmarks of significance by several orders of magnitude for both schizophrenia (P=2.5 × 10(-11), odds ratio (OR) 1.10, 95% confidence interval 1.07-1.14) and schizophrenia and bipolar disorder combined (P=4.1 × 10(-13), OR 1.11, 95% confidence interval 1.07-1.14). After de novo polymorphism discovery and detailed association analysis, rs1344706 remained the most strongly associated marker in the gene. The allelic association at the ZNF804A locus is now one of the most compelling in schizophrenia to date, and supports the accumulating data suggesting overlapping genetic risk between schizophrenia and bipolar disorder.
    Item Type
    Article
    Language
    en
    ISSN
    1476-5578
    ae974a485f413a2113503eed53cd6c53
    10.1038/mp.2010.36
    Scopus Count
    Collections
    St. James's Hospital

    entitlement

    Related articles

    • Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706.
    • Authors: Tao R, Cousijn H, Jaffe AE, Burnet PW, Edwards F, Eastwood SL, Shin JH, Lane TA, Walker MA, Maher BJ, Weinberger DR, Harrison PJ, Hyde TM, Kleinman JE
    • Issue date: 2014 Oct
    • Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex.
    • Authors: Guella I, Sequeira A, Rollins B, Morgan L, Myers RM, Watson SJ, Akil H, Bunney WE, Delisi LE, Byerley W, Vawter MP
    • Issue date: 2014 Jan
    • ZNF804A Genetic Variation Confers Risk to Bipolar Disorder.
    • Authors: Zhang C, Wang Z, Hong W, Wu Z, Peng D, Fang Y
    • Issue date: 2016 Jul
    • ZNF804A and cortical thickness in schizophrenia and bipolar disorder.
    • Authors: Bergmann O, Haukvik UK, Brown AA, Rimol LM, Hartberg CB, Athanasiu L, Melle I, Djurovic S, Andreassen OA, Dale AM, Agartz I
    • Issue date: 2013 May 30
    • Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations.
    • Authors: Rao S, Yao Y, Ryan J, Jin C, Xu Y, Huang X, Guo J, Wen Y, Mao C, Meyre D, Zhang F
    • Issue date: 2017 Jan 25
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.