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dc.contributor.authorHassan, Tidi
dc.contributor.authorMcKiernan, Paul J
dc.contributor.authorMcElvaney, Noel G
dc.contributor.authorCryan, Sally Ann
dc.contributor.authorGreene, Catherine M
dc.date.accessioned2012-06-29T14:11:20Z
dc.date.available2012-06-29T14:11:20Z
dc.date.issued2012-03
dc.identifier.citationTherapeutic modulation of miRNA for the treatment of proinflammatory lung diseases. 2012, 10 (3):359-68 Expert Rev Anti Infect Theren_GB
dc.identifier.issn1744-8336
dc.identifier.pmid22397568
dc.identifier.doi10.1586/eri.11.175
dc.identifier.urihttp://hdl.handle.net/10147/231513
dc.description.abstractmiRNAs are short, nonprotein coding RNAs that regulate target gene expression principally by causing translational repression and/or mRNA degradation. miRNAs are involved in most mammalian biological processes and have pivotal roles in controlling the expression of factors involved in basal and stimulus-induced signaling pathways. Considering their central role in the regulation of gene expression, miRNAs represent therapeutic drug targets. Here we describe how miRNAs are involved in the regulation of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.
dc.language.isoenen
dc.rightsArchived with thanks to Expert review of anti-infective therapyen_GB
dc.subject.meshGene Expression Regulation
dc.subject.meshGene Targeting
dc.subject.meshHumans
dc.subject.meshImmunity, Innate
dc.subject.meshInflammation
dc.subject.meshLung Diseases
dc.subject.meshMicroRNAs
dc.titleTherapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.en_GB
dc.typeArticleen
dc.contributor.departmentRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.en_GB
dc.identifier.journalExpert review of anti-infective therapyen_GB
dc.description.provinceLeinsteren
html.description.abstractmiRNAs are short, nonprotein coding RNAs that regulate target gene expression principally by causing translational repression and/or mRNA degradation. miRNAs are involved in most mammalian biological processes and have pivotal roles in controlling the expression of factors involved in basal and stimulus-induced signaling pathways. Considering their central role in the regulation of gene expression, miRNAs represent therapeutic drug targets. Here we describe how miRNAs are involved in the regulation of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.


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